Level and distribution of microtubule-associated protein-2 (MAP2) as an index of dendritic structural dynamics

Giuseppina Di Stefano, Tiziana Casoli, Patrizia Fattoretti, Marta Balietti, Yessica Grossi, Belinda Giorgetti, Carlo Bertoni-Freddari

Research output: Contribution to journalArticlepeer-review

Abstract

Optical density of MAP2 immunoreactivity (OD), the ratio between the MAP2 stained area/total test area (area fraction: AF), the total length of MAP2 labeled profiles (TL) and the ratio perimeter/area of the immunostained profiles (pleomorphism index [PI]) were measured by quantitative immunohistochemistry in the brain of rats of different ages. In old rats versus young and adult animals, OD and AF were significantly lower, whereas PI was significantly higher, in dentate gyrus molecular layer, CA1 stratum radiatum and olfactory bulb. These findings lend support to the many converging results on the higher vulnerability to aging of the CNS areas featuring higher plasticity.

Original languageEnglish
Pages (from-to)94-98
Number of pages5
JournalRejuvenation Research
Volume9
Issue number1
DOIs
Publication statusPublished - Mar 2006

ASJC Scopus subject areas

  • Ageing

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