Level of nerve growth factor and distribution of mast cells in the synovium of tumour necrosis factor transgenic arthritic mice

L. Aloe, L. Probert, G. Kollias, L. Bracci-Laudiero, A. Micera, C. Mollinari, R. Levi-Montalcini

Research output: Contribution to journalArticlepeer-review

Abstract

We have recently reported that nerve growth factor (NGF) increases in the synovium of patients affected by arthritis, as well as in animal models. We report here that the synovium of transgenic arthritic mice expressing human tumour necrosis factor (TNF) contains numerous mast cells (MC) and that their appearance is a phenomenon which was correlated to the local increase in NGF level. These findings provide further evidence that NGF plays a role in inflammation and suggest a functional link between NGF and MC.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalInternational Journal of Tissue Reactions
Volume15
Issue number4
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Cell Biology
  • Physiology

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