Level of sedation evaluation with cerebral state index and A-line Arx in children undergoing diagnostic procedures

Nicola Disma, Daniela Lauretta, Filippo Palermo, Danila Sapienza, Pablo Mauricio Ingelmo, Marinella Astuto

Research output: Contribution to journalArticlepeer-review


Background: Monitoring of anesthesia depth is difficult clinically, particularly in children. The aim of this study was to assess the correlation existing between CSI (Cerebral State Index), or AAI (A-line ARX) and a clinical sedation scale such as UMSS (University of Michigan Sedation Scale), during deep sedation with propofol in children undergoing diagnostic procedures. Methods: Twenty ASA I and II children, scheduled to undergo deep sedation for magnetic resonance imaging (MRI) or Esophagogastroduodenoscopy (EGDS), were enrolled. The patients were randomly assigned to receive depth of anesthesia monitoring with CSI or AAI. The anesthetist administered repeated doses of propofol every 10 s to a UMSS score of 3-4. An attending anesthetist, not involved in drug administration, recorded time and doses of sedation medications, vital signs, UMSS score and CSI or AAI score. All the evaluations were recorded at awake state (baseline), every 10 s until an UMSS score of 3-4 and every 3 min until the children were awake. Results: We enrolled 13 males and seven females ranging in age from 8 months to 7 years. After induction of anesthesia CSI and AAI scores decreased and from the end of the procedure to emergence the two scores increased. The CSI data showed a strong correlation with the UMSS scores (r = -0.861; P <0.0001); we found a similar correlation between the AAI data and the UMSS scores (r = -0.823; P <0.0001). Conclusions: Our study suggests that CSI and AAI may be two, real-time and objective tools to assess induction and emergence during propofol sedation in children undergoing EGDS and MRI.

Original languageEnglish
Pages (from-to)445-451
Number of pages7
JournalPaediatric Anaesthesia
Issue number5
Publication statusPublished - May 2007


  • Auditory evoked potential
  • Cerebral state index
  • Children
  • Diagnostic procedures
  • Propofol
  • Sedation

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Pediatrics, Perinatology, and Child Health


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