Livelli di CCL2 e VEGF nel tessuto patologico e nell'endometrio eutopico nelle donne con endometriosi ovarica

Objective: To investigate the role of an inflammatory mediator, like CCL2, and an angiogenic factor, like VEGF in the pathogenesis of endometriosis. Our aim is to consider if a different concentration of these factors could justified the ectopic infiltration and progression of the disease. Materials and methods: We observed 36 women in fertile age: 18 women with ovarian endometriosis and 18 patients with a benign cystic ovarian disease, diagnosed during surgical evaluation. Pathological tissue and eutopic endometrium samples were collected during surgery and then processed in order to obtain a biological fluid, then examined by Enzime-liked immunoassorbent assay (ELISA). Results: The levels of CCL2 in women with ovarian endometriosis were significantly higher than in the control group (p value = 0,009). In women with ovarian endometriosis the levels of VEGF in the eutopic endometrium were significantly higher than in the control group (p value = 0,04). Conclusions: Our results suggest that CCL2 and VEGF could have a role in the development and progression of endometriosis. The levels of these mediators in eutopic endometrium in women with ovarian endometriosis could reveal a predisposition to develop the disease.