The levels of diazepam and its N-desmethyl metabolites were measured in adipose tissue of rats and mice, at different times after administration of diazepam (5 mg/kg i.v.). In the adpose tissue there was a progressive accumulation of diazepam for up to 30 min after injection and even after 5 hr diazepam was measurable. Diazepam was present in both white (epidydimal) and brown (intrascapular) adipose tissue. In rats N-desmethyl metabolites were present only in traces while in mice they reached high levels. In humans diazepam was detectable in the scapular adipose tissue only 30 and 60 min after intravenous injection of 10 mg of the drug, while at earlier or later times the levels were under 25 ng/g.
|Number of pages||3|
|Journal||European Journal of Pharmacology|
|Publication status||Published - Nov 1968|
- Adipose tissue
- N-desmethyl diazepam
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience