Levels of diazepam in adipose tissue of rats, mice and man

F. Marcucci, R. Fanelli, M. Frova, P. L. Morselli

Research output: Contribution to journalArticle

Abstract

The levels of diazepam and its N-desmethyl metabolites were measured in adipose tissue of rats and mice, at different times after administration of diazepam (5 mg/kg i.v.). In the adpose tissue there was a progressive accumulation of diazepam for up to 30 min after injection and even after 5 hr diazepam was measurable. Diazepam was present in both white (epidydimal) and brown (intrascapular) adipose tissue. In rats N-desmethyl metabolites were present only in traces while in mice they reached high levels. In humans diazepam was detectable in the scapular adipose tissue only 30 and 60 min after intravenous injection of 10 mg of the drug, while at earlier or later times the levels were under 25 ng/g.

Original languageEnglish
Pages (from-to)464-466
Number of pages3
JournalEuropean Journal of Pharmacology
Volume4
Issue number4
Publication statusPublished - Nov 1968

Keywords

  • Adipose tissue
  • Diazepam
  • N-desmethyl diazepam

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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    Marcucci, F., Fanelli, R., Frova, M., & Morselli, P. L. (1968). Levels of diazepam in adipose tissue of rats, mice and man. European Journal of Pharmacology, 4(4), 464-466.