Levels of epidermal growth factor in mice tissues measured by a specific radioreceptor assay

L. Frati, G. Cenci, G. Sbaraglia, Diana Venza Teti, I. Covelli

Research output: Contribution to journalArticlepeer-review

Abstract

A radioreceptor assay of Epidermal Growth Factor (EGF), which uses as binder plasma membranes prepared from target tissues, instead of specific antibodies, is described. The amount of the polypeptide hormone present in the homogenate has been measured in various tissues. Submaxillary gland and parotid are confirmed to possess the highest levels of the factor. Results obtained incubating sliced tissues with or without pilocarpine, a drug which stimulates the hormone release, suggest that the tissues under investigation can be classified in two groups: a - "target tissues" (i.e. epidermis and corneal epithelium) b- "synthetizing" tissues (i.e. submaxillary gland, parotid, liver), which release the factor under pilocarpine stimulation.

Original languageEnglish
Pages (from-to)905-911
Number of pages7
JournalLife Sciences
Volume18
Issue number9
DOIs
Publication statusPublished - May 1 1976

ASJC Scopus subject areas

  • Pharmacology

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