Levels of epidermal growth factor in mice tissues measured by a specific radioreceptor assay

L. Frati, G. Cenci, G. Sbaraglia, D. V. Teti, I. Covelli

Research output: Contribution to journalArticle

Abstract

A radioreceptor assay of the Epidermal Growth Factor (EGF), which uses as binder plasma membranes prepared from target tissues instead of specific antibodies, is described. The amount of the polypeptide hormone present in the homogenate was measured in various tissues. Submaxillary gland and parotid are confirmed to possess the highest levels of the factor. Results obtained by incubating sliced tissues with or without pilocarpine, a drug which stimulates the hormone release, suggest that the tissues under investigation can be classified in 2 groups: a 'target tissues' (i.e. epidermis and corneal epithelium), and 'synthetizing' tissues (i.e. submaxillary gland, parotid, liver), which release the factor under pilocarpine stimulation.

Original languageEnglish
Pages (from-to)905-912
Number of pages8
JournalLife Sciences
Volume18
Issue number9
DOIs
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Levels of epidermal growth factor in mice tissues measured by a specific radioreceptor assay'. Together they form a unique fingerprint.

  • Cite this