Brain cortex levels of 21 free aminoacids in adult cats during convulsions and EEG spike activity induced by exposure to high oxygen pressure have been studied. Experimental convulsions were elicited in a hyperbaric room in 12 cats, monitored by continous EEG recordings. Five of these animals had prolonged convulsions after removal from the hyperbaric room ('off effect') and were selected for aminoacid level measurements. Twelve untreated cats were used as the control group, and five of these were randomly selected for brain aminoacid level determinations. Our data showed a highly significant increase of Glutamic Acid and Glutamine and a significant decrease of GABA in the brains of the cats sacrificed during 'off effect', while the other animoacid levels did not vary significantly. These data confirm previously reported observations, and stress the role of GABA and its precursors in biochemical mechanisms of hyperoxic convulsions.
|Number of pages||1|
|Journal||IRCS Medical Science|
|Publication status||Published - 1981|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)