Levels of growth differentiation factor-15 are high and correlate with clinical severity in transfusion-independent patients with β thalassemia intermedia

Khaled M. Musallam, Ali T. Taher, Lorena Duca, Claudia Cesaretti, Racha Halawi, Maria Domenica Cappellini

Research output: Contribution to journalArticle

Abstract

Transfusion-independent patients with thalassemia intermedia (TI) experience a variety of clinical complications attributed to the underlying ineffective erythropoiesis and subsequent anemia, hemolysis, and iron overload. Growth differentiation factor-15 (GDF-15) was recently investigated as a marker of ineffective erythropoiesis in several anemias. In this work, we evaluated GDF-15 levels in 55 patients with TI. The mean GDF-15 level was 25,197.8.. 16,208.9. pg/ml which is lower than values reported for patients with thalassemia major, yet considerably higher than those reported in patients with other congenital and acquired anemias. GDF-15 levels were significantly higher in splenectomized compared to non-splenectomized patients and correlated with anemia, markers of iron overload, and a pre-defined clinical severity score. Further studies are needed to determine the practical utility of GDF-15 measurement and its potential to reflect the severity of the clinical course in TI patients.

Original languageEnglish
Pages (from-to)232-234
Number of pages3
JournalBlood cells, molecules & diseases
Volume47
Issue number4
DOIs
Publication statusPublished - Dec 15 2011

Keywords

  • Clinical complications
  • Growth differentiation factor-15
  • Ineffective erythropoiesis
  • Iron overload
  • Thalassemia intermedia

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Hematology
  • Cell Biology

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