Levels of human tissue kallikrein in the vitreous fluid of patients with severe proliferative diabetic retinopathy

Antonio Pinna, Costanza Emanueli, Stefano Dore, Marco Salvo, Paolo Madeddu, Francesco Carta

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to determine the levels of human tissue kallikrein in the vitreous fluid of patients with severe proliferative diabetic retinopathy (PDR). Tissue kallikrein levels were measured using a specific ELISA (range: 0.4-25 ng/ml) in 7 vitreous fluids from eyes with severe PDR. Seven vitreous samples from eyes which underwent vitrectomy because of rhegmatogenous retinal detachment served as non-PDR controls. Enzymatic activity was also tested by an amidolytic assay using a chromogenic substrate. In the PDR patients, vitreous tissue kallikrein was

Original languageEnglish
Pages (from-to)260-263
Number of pages4
JournalOphthalmologica
Volume218
Issue number4
DOIs
Publication statusPublished - 2004

Keywords

  • Amidolytic test
  • ELISA
  • Human tissue kallikrein
  • Pars plana vitrectomy
  • Proliferative diabetic retinopathy
  • Vitreous
  • Vitreous hemorrhage

ASJC Scopus subject areas

  • Ophthalmology

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