Levels of Ia-like antigen bearing lymphocytes in patients with solid primary tumors

P. Cordiali-Fei, P. G. Natali, G. Pecci, M. A. Pellegrino, S. Ferrone

Research output: Contribution to journalArticle

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Abstract

In patients with different types of solid tumors who had no detectable metastasis and had received no radio- and chemotherapy the levels of Ia-like antigen bearing lymphocytes was determined by indirect immunofluorescence staining of peripheral lymphocytes with xenoantisera to framework determinants of Ia-like antigens. The level of Ia-like antigen bearing lymphocytes was increased in patients with urinary bladder carcinoma, was decreased in patients with carcinoma of the gastro-intestinal tract and was within normal ranges in patients with melanoma, carcinomas of the breast, lung and genital tract. In patients with carcinomas of the gastrointestinal tract as well as in patients with carcinoma of lung and genital tract the level of T lymphocytes measured by rosetting with sheep red blood cells, was reduced while it was not different from normal in other groups of patients. Determination of the level of lymphocyte subpopulations may provide information about the immunocompetence status of patients with solid tumors.

Original languageEnglish
Pages (from-to)197-199
Number of pages3
JournalJournal of Clinical and Laboratory Immunology
Volume6
Issue number3
Publication statusPublished - 1981

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Histocompatibility Antigens Class II
Lymphocytes
Neoplasms
Carcinoma
Immunocompetence
Lung
Lymphocyte Subsets
Indirect Fluorescent Antibody Technique
Gastrointestinal Tract
Melanoma
Sheep
Reference Values
Urinary Bladder
Radiotherapy
Erythrocytes
Staining and Labeling
Breast Neoplasms
Neoplasm Metastasis
T-Lymphocytes
Drug Therapy

ASJC Scopus subject areas

  • Immunology

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Cordiali-Fei, P., Natali, P. G., Pecci, G., Pellegrino, M. A., & Ferrone, S. (1981). Levels of Ia-like antigen bearing lymphocytes in patients with solid primary tumors. Journal of Clinical and Laboratory Immunology, 6(3), 197-199.

Levels of Ia-like antigen bearing lymphocytes in patients with solid primary tumors. / Cordiali-Fei, P.; Natali, P. G.; Pecci, G.; Pellegrino, M. A.; Ferrone, S.

In: Journal of Clinical and Laboratory Immunology, Vol. 6, No. 3, 1981, p. 197-199.

Research output: Contribution to journalArticle

Cordiali-Fei, P, Natali, PG, Pecci, G, Pellegrino, MA & Ferrone, S 1981, 'Levels of Ia-like antigen bearing lymphocytes in patients with solid primary tumors', Journal of Clinical and Laboratory Immunology, vol. 6, no. 3, pp. 197-199.
Cordiali-Fei, P. ; Natali, P. G. ; Pecci, G. ; Pellegrino, M. A. ; Ferrone, S. / Levels of Ia-like antigen bearing lymphocytes in patients with solid primary tumors. In: Journal of Clinical and Laboratory Immunology. 1981 ; Vol. 6, No. 3. pp. 197-199.
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