Abstract
The relation between pro-inflammatory cytokines and psoriasis represents one of the main fields explored in the last years. Using the experimental approach of measuring cytokines released by skin organ cultures, IL-1α, IL-6 and IL-8 were dosed in 10 biopsy supernatants of lesional and non-lesional psoriatic skin areas as well as in those of 10 normal volunteers. Data obtained showed that the spontaneous release of such mediators are significantly increased (p <= 0.01) in the psoriatic lesional skin as compared to the nonlesional and to the normal skin. Since all these cytokines exert pro-inflammatory activities, the association between psoriatic lesion and high released levels of such mediators may have pathogenetic relevance.
| Original language | English |
|---|---|
| Pages (from-to) | 83-84 |
| Number of pages | 2 |
| Journal | International Journal of Immunopathology and Pharmacology |
| Volume | 10 |
| Issue number | 1 |
| Publication status | Published - 1997 |
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Keywords
- IL-1α
- IL-6
- IL-8
- PASI
- psoriasis
- skin culture supernatants
ASJC Scopus subject areas
- Pharmacology
Cite this
Ameglio, F., Bonifatf, C., Fazio, M., Mussi, A., Trento, E., Cordiali Fei, P., Donati, P., Pimpinelli, F., D'Auria, L., Alemanno, L., & Carducci, M. (1997). Levels of IL-1α, IL-6 and IL-8 in organ culture supernatants of psoriatic lesional skin. International Journal of Immunopathology and Pharmacology, 10(1), 83-84.