The relation between pro-inflammatory cytokines and psoriasis represents one of the main fields explored in the last years. Using the experimental approach of measuring cytokines released by skin organ cultures, IL-1α, IL-6 and IL-8 were dosed in 10 biopsy supernatants of lesional and non-lesional psoriatic skin areas as well as in those of 10 normal volunteers. Data obtained showed that the spontaneous release of such mediators are significantly increased (p <= 0.01) in the psoriatic lesional skin as compared to the nonlesional and to the normal skin. Since all these cytokines exert pro-inflammatory activities, the association between psoriatic lesion and high released levels of such mediators may have pathogenetic relevance.
|Number of pages||2|
|Journal||International Journal of Immunopathology and Pharmacology|
|Publication status||Published - 1997|
- skin culture supernatants
ASJC Scopus subject areas