Abstract
The relation between pro-inflammatory cytokines and psoriasis represents one of the main fields explored in the last years. Using the experimental approach of measuring cytokines released by skin organ cultures, IL-1α, IL-6 and IL-8 were dosed in 10 biopsy supernatants of lesional and non-lesional psoriatic skin areas as well as in those of 10 normal volunteers. Data obtained showed that the spontaneous release of such mediators are significantly increased (p <= 0.01) in the psoriatic lesional skin as compared to the nonlesional and to the normal skin. Since all these cytokines exert pro-inflammatory activities, the association between psoriatic lesion and high released levels of such mediators may have pathogenetic relevance.
Original language | English |
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Pages (from-to) | 83-84 |
Number of pages | 2 |
Journal | International Journal of Immunopathology and Pharmacology |
Volume | 10 |
Issue number | 1 |
Publication status | Published - 1997 |
Keywords
- IL-1α
- IL-6
- IL-8
- PASI
- psoriasis
- skin culture supernatants
ASJC Scopus subject areas
- Pharmacology