Levels of IL-1α, IL-6 and IL-8 in organ culture supernatants of psoriatic lesional skin

F. Ameglio; C. Bonifatf; M. Fazio; A. Mussi; E. Trento; P. Cordiali Fei; P. Donati; F. Pimpinelli; L. D'Auria; L. Alemanno; M. Carducci

Levels of IL-1α, IL-6 and IL-8 in organ culture supernatants of psoriatic lesional skin

F. Ameglio, C. Bonifatf, M. Fazio, A. Mussi, E. Trento, P. Cordiali Fei, P. Donati, F. Pimpinelli, L. D'Auria, L. Alemanno, M. Carducci

Istituto S. Maria e S. Gallicano

Research output: Contribution to journal › Article › peer-review

Abstract

The relation between pro-inflammatory cytokines and psoriasis represents one of the main fields explored in the last years. Using the experimental approach of measuring cytokines released by skin organ cultures, IL-1α, IL-6 and IL-8 were dosed in 10 biopsy supernatants of lesional and non-lesional psoriatic skin areas as well as in those of 10 normal volunteers. Data obtained showed that the spontaneous release of such mediators are significantly increased (p <= 0.01) in the psoriatic lesional skin as compared to the nonlesional and to the normal skin. Since all these cytokines exert pro-inflammatory activities, the association between psoriatic lesion and high released levels of such mediators may have pathogenetic relevance.

Original language	English
Pages (from-to)	83-84
Number of pages	2
Journal	International Journal of Immunopathology and Pharmacology
Volume	10
Issue number	1
Publication status	Published - 1997

Keywords

IL-1α
IL-6
IL-8
PASI
psoriasis
skin culture supernatants

ASJC Scopus subject areas

Pharmacology

Cite this

Levels of IL-1α, IL-6 and IL-8 in organ culture supernatants of psoriatic lesional skin. / Ameglio, F.; Bonifatf, C.; Fazio, M.; Mussi, A.; Trento, E.; Cordiali Fei, P.; Donati, P.; Pimpinelli, F.; D'Auria, L.; Alemanno, L.; Carducci, M.

In: International Journal of Immunopathology and Pharmacology, Vol. 10, No. 1, 1997, p. 83-84.

Research output: Contribution to journal › Article › peer-review

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abstract = "The relation between pro-inflammatory cytokines and psoriasis represents one of the main fields explored in the last years. Using the experimental approach of measuring cytokines released by skin organ cultures, IL-1α, IL-6 and IL-8 were dosed in 10 biopsy supernatants of lesional and non-lesional psoriatic skin areas as well as in those of 10 normal volunteers. Data obtained showed that the spontaneous release of such mediators are significantly increased (p <= 0.01) in the psoriatic lesional skin as compared to the nonlesional and to the normal skin. Since all these cytokines exert pro-inflammatory activities, the association between psoriatic lesion and high released levels of such mediators may have pathogenetic relevance.",

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AU - Ameglio, F.

AU - Bonifatf, C.

AU - Fazio, M.

AU - Mussi, A.

AU - Trento, E.

AU - Cordiali Fei, P.

AU - Donati, P.

AU - Pimpinelli, F.

AU - D'Auria, L.

AU - Alemanno, L.

AU - Carducci, M.

PY - 1997

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N2 - The relation between pro-inflammatory cytokines and psoriasis represents one of the main fields explored in the last years. Using the experimental approach of measuring cytokines released by skin organ cultures, IL-1α, IL-6 and IL-8 were dosed in 10 biopsy supernatants of lesional and non-lesional psoriatic skin areas as well as in those of 10 normal volunteers. Data obtained showed that the spontaneous release of such mediators are significantly increased (p <= 0.01) in the psoriatic lesional skin as compared to the nonlesional and to the normal skin. Since all these cytokines exert pro-inflammatory activities, the association between psoriatic lesion and high released levels of such mediators may have pathogenetic relevance.

AB - The relation between pro-inflammatory cytokines and psoriasis represents one of the main fields explored in the last years. Using the experimental approach of measuring cytokines released by skin organ cultures, IL-1α, IL-6 and IL-8 were dosed in 10 biopsy supernatants of lesional and non-lesional psoriatic skin areas as well as in those of 10 normal volunteers. Data obtained showed that the spontaneous release of such mediators are significantly increased (p <= 0.01) in the psoriatic lesional skin as compared to the nonlesional and to the normal skin. Since all these cytokines exert pro-inflammatory activities, the association between psoriatic lesion and high released levels of such mediators may have pathogenetic relevance.

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Levels of IL-1α, IL-6 and IL-8 in organ culture supernatants of psoriatic lesional skin

Abstract

Keywords

ASJC Scopus subject areas

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