Abstract
The relation between pro-inflammatory cytokines and psoriasis represents one of the main fields explored in the last years. Using the experimental approach of measuring cytokines released by skin organ cultures, IL-1α, IL-6 and IL-8 were dosed in 10 biopsy supernatants of lesional and non-lesional psoriatic skin areas as well as in those of 10 normal volunteers. Data obtained showed that the spontaneous release of such mediators are significantly increased (p <= 0.01) in the psoriatic lesional skin as compared to the nonlesional and to the normal skin. Since all these cytokines exert pro-inflammatory activities, the association between psoriatic lesion and high released levels of such mediators may have pathogenetic relevance.
| Original language | English |
|---|---|
| Pages (from-to) | 83-84 |
| Number of pages | 2 |
| Journal | International Journal of Immunopathology and Pharmacology |
| Volume | 10 |
| Issue number | 1 |
| Publication status | Published - 1997 |
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Keywords
- IL-1α
- IL-6
- IL-8
- PASI
- psoriasis
- skin culture supernatants
ASJC Scopus subject areas
- Pharmacology
Cite this
Levels of IL-1α, IL-6 and IL-8 in organ culture supernatants of psoriatic lesional skin. / Ameglio, F.; Bonifatf, C.; Fazio, M.; Mussi, A.; Trento, E.; Cordiali Fei, P.; Donati, P.; Pimpinelli, F.; D'Auria, L.; Alemanno, L.; Carducci, M.
In: International Journal of Immunopathology and Pharmacology, Vol. 10, No. 1, 1997, p. 83-84.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Levels of IL-1α, IL-6 and IL-8 in organ culture supernatants of psoriatic lesional skin
AU - Ameglio, F.
AU - Bonifatf, C.
AU - Fazio, M.
AU - Mussi, A.
AU - Trento, E.
AU - Cordiali Fei, P.
AU - Donati, P.
AU - Pimpinelli, F.
AU - D'Auria, L.
AU - Alemanno, L.
AU - Carducci, M.
PY - 1997
Y1 - 1997
N2 - The relation between pro-inflammatory cytokines and psoriasis represents one of the main fields explored in the last years. Using the experimental approach of measuring cytokines released by skin organ cultures, IL-1α, IL-6 and IL-8 were dosed in 10 biopsy supernatants of lesional and non-lesional psoriatic skin areas as well as in those of 10 normal volunteers. Data obtained showed that the spontaneous release of such mediators are significantly increased (p <= 0.01) in the psoriatic lesional skin as compared to the nonlesional and to the normal skin. Since all these cytokines exert pro-inflammatory activities, the association between psoriatic lesion and high released levels of such mediators may have pathogenetic relevance.
AB - The relation between pro-inflammatory cytokines and psoriasis represents one of the main fields explored in the last years. Using the experimental approach of measuring cytokines released by skin organ cultures, IL-1α, IL-6 and IL-8 were dosed in 10 biopsy supernatants of lesional and non-lesional psoriatic skin areas as well as in those of 10 normal volunteers. Data obtained showed that the spontaneous release of such mediators are significantly increased (p <= 0.01) in the psoriatic lesional skin as compared to the nonlesional and to the normal skin. Since all these cytokines exert pro-inflammatory activities, the association between psoriatic lesion and high released levels of such mediators may have pathogenetic relevance.
KW - IL-1α
KW - IL-6
KW - IL-8
KW - PASI
KW - psoriasis
KW - skin culture supernatants
UR - http://www.scopus.com/inward/record.url?scp=12644282522&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12644282522&partnerID=8YFLogxK
M3 - Article
VL - 10
SP - 83
EP - 84
JO - International Journal of Immunopathology and Pharmacology
JF - International Journal of Immunopathology and Pharmacology
SN - 0394-6320
IS - 1
ER -