Abstract
Structured treatment interruption (STI) may help to alleviate the problems associated with long-term antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-infected patients. We analyzed the role that baseline levels of cytokines in plasma play as markers of a favorable outcome of STI. Two groups of patients were defined: STI responders and STI nonresponders. STI responders showed a higher baseline concentration of interleukin (IL)-15 in plasma than did STI nonresponders and showed lower levels of tumor necrosis factor (TNF)-α during STI. No differences were observed in levels of IL-2, IL-7, or interferon-α in plasma. Our data show that (1) levels of TNF-α in plasma correlate with HIV viremia and (2) monitoring baseline levels of IL-15 in plasma allows for the identification of a favorable outcome of STI.
Original language | English |
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Pages (from-to) | 661-665 |
Number of pages | 5 |
Journal | Journal of Infectious Diseases |
Volume | 188 |
Issue number | 5 |
DOIs | |
Publication status | Published - Sep 1 2003 |
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology