Levels of non-transferrin-bound iron as an index of iron overload in patients with thalassaemia intermedia

Ali Taher; Khaled M. Musallam; Fouad El Rassi; Lorena Duca; Adlette Inati; Suzane Koussa; Maria D. Cappellini

doi:10.1111/j.1365-2141.2009.07810.x

Levels of non-transferrin-bound iron as an index of iron overload in patients with thalassaemia intermedia

Ali Taher, Khaled M. Musallam, Fouad El Rassi, Lorena Duca, Adlette Inati, Suzane Koussa, Maria D. Cappellini

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Non-transferrin-bound iron (NTBI) was evaluated as an index of iron overload in a cross-sectional randomised study in 74 non-transfused patients with thalassaemia intermedia (TI). Mean NTBI (2.92 ± 3.43 μmol/l), serum ferritin (1023 ± 780 ng/ml) and liver iron concentration (LIC; 9.0 ± 7.4 mg Fe/g dry weight) were increased above reference-range levels. Significant positive correlations occurred between mean NTBI and LIC (Pearson correlation 0.36; P = 0.002) and serum ferritin (Pearson correlation 0.421; P <0.0001); with higher levels observed in splenectomised patients. NTBI assessment has potential as a simple reliable approach to determining iron status in TI.

Original language	English
Pages (from-to)	569-572
Number of pages	4
Journal	British Journal of Haematology
Volume	146
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2141.2009.07810.x
Publication status	Published - Sep 2009

Keywords

Iron overload
Non-transferrin-bound iron
Thalassaemia intermedia

ASJC Scopus subject areas

Hematology

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title = "Levels of non-transferrin-bound iron as an index of iron overload in patients with thalassaemia intermedia",

abstract = "Non-transferrin-bound iron (NTBI) was evaluated as an index of iron overload in a cross-sectional randomised study in 74 non-transfused patients with thalassaemia intermedia (TI). Mean NTBI (2.92 ± 3.43 μmol/l), serum ferritin (1023 ± 780 ng/ml) and liver iron concentration (LIC; 9.0 ± 7.4 mg Fe/g dry weight) were increased above reference-range levels. Significant positive correlations occurred between mean NTBI and LIC (Pearson correlation 0.36; P = 0.002) and serum ferritin (Pearson correlation 0.421; P <0.0001); with higher levels observed in splenectomised patients. NTBI assessment has potential as a simple reliable approach to determining iron status in TI.",

keywords = "Iron overload, Non-transferrin-bound iron, Thalassaemia intermedia",

author = "Ali Taher and Musallam, {Khaled M.} and {El Rassi}, Fouad and Lorena Duca and Adlette Inati and Suzane Koussa and Cappellini, {Maria D.}",

year = "2009",

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AU - Taher, Ali

AU - Musallam, Khaled M.

AU - El Rassi, Fouad

AU - Duca, Lorena

AU - Inati, Adlette

AU - Koussa, Suzane

AU - Cappellini, Maria D.

PY - 2009/9

Y1 - 2009/9

N2 - Non-transferrin-bound iron (NTBI) was evaluated as an index of iron overload in a cross-sectional randomised study in 74 non-transfused patients with thalassaemia intermedia (TI). Mean NTBI (2.92 ± 3.43 μmol/l), serum ferritin (1023 ± 780 ng/ml) and liver iron concentration (LIC; 9.0 ± 7.4 mg Fe/g dry weight) were increased above reference-range levels. Significant positive correlations occurred between mean NTBI and LIC (Pearson correlation 0.36; P = 0.002) and serum ferritin (Pearson correlation 0.421; P <0.0001); with higher levels observed in splenectomised patients. NTBI assessment has potential as a simple reliable approach to determining iron status in TI.

AB - Non-transferrin-bound iron (NTBI) was evaluated as an index of iron overload in a cross-sectional randomised study in 74 non-transfused patients with thalassaemia intermedia (TI). Mean NTBI (2.92 ± 3.43 μmol/l), serum ferritin (1023 ± 780 ng/ml) and liver iron concentration (LIC; 9.0 ± 7.4 mg Fe/g dry weight) were increased above reference-range levels. Significant positive correlations occurred between mean NTBI and LIC (Pearson correlation 0.36; P = 0.002) and serum ferritin (Pearson correlation 0.421; P <0.0001); with higher levels observed in splenectomised patients. NTBI assessment has potential as a simple reliable approach to determining iron status in TI.

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KW - Thalassaemia intermedia

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