Abstract
Non-transferrin-bound iron (NTBI) was evaluated as an index of iron overload in a cross-sectional randomised study in 74 non-transfused patients with thalassaemia intermedia (TI). Mean NTBI (2.92 ± 3.43 μmol/l), serum ferritin (1023 ± 780 ng/ml) and liver iron concentration (LIC; 9.0 ± 7.4 mg Fe/g dry weight) were increased above reference-range levels. Significant positive correlations occurred between mean NTBI and LIC (Pearson correlation 0.36; P = 0.002) and serum ferritin (Pearson correlation 0.421; P <0.0001); with higher levels observed in splenectomised patients. NTBI assessment has potential as a simple reliable approach to determining iron status in TI.
Original language | English |
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Pages (from-to) | 569-572 |
Number of pages | 4 |
Journal | British Journal of Haematology |
Volume | 146 |
Issue number | 5 |
DOIs | |
Publication status | Published - Sep 2009 |
Keywords
- Iron overload
- Non-transferrin-bound iron
- Thalassaemia intermedia
ASJC Scopus subject areas
- Hematology