Levels of non-transferrin-bound iron as an index of iron overload in patients with thalassaemia intermedia

Ali Taher, Khaled M. Musallam, Fouad El Rassi, Lorena Duca, Adlette Inati, Suzane Koussa, Maria D. Cappellini

Research output: Contribution to journalArticlepeer-review

Abstract

Non-transferrin-bound iron (NTBI) was evaluated as an index of iron overload in a cross-sectional randomised study in 74 non-transfused patients with thalassaemia intermedia (TI). Mean NTBI (2.92 ± 3.43 μmol/l), serum ferritin (1023 ± 780 ng/ml) and liver iron concentration (LIC; 9.0 ± 7.4 mg Fe/g dry weight) were increased above reference-range levels. Significant positive correlations occurred between mean NTBI and LIC (Pearson correlation 0.36; P = 0.002) and serum ferritin (Pearson correlation 0.421; P <0.0001); with higher levels observed in splenectomised patients. NTBI assessment has potential as a simple reliable approach to determining iron status in TI.

Original languageEnglish
Pages (from-to)569-572
Number of pages4
JournalBritish Journal of Haematology
Volume146
Issue number5
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Iron overload
  • Non-transferrin-bound iron
  • Thalassaemia intermedia

ASJC Scopus subject areas

  • Hematology

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