Abstract
1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.
| Original language | English |
|---|---|
| Pages (from-to) | 595-600 |
| Number of pages | 6 |
| Journal | Xenobiotica |
| Volume | 5 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1975 |
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ASJC Scopus subject areas
- Pharmacology
- Toxicology
- Biochemistry
- Health, Toxicology and Mutagenesis
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Levels of piribedil and its active metabolite (s-584) in the rat striatum. / Fanelli, R.; Frigerio, A.; Garattini, S.
In: Xenobiotica, Vol. 5, No. 10, 1975, p. 595-600.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Levels of piribedil and its active metabolite (s-584) in the rat striatum
AU - Fanelli, R.
AU - Frigerio, A.
AU - Garattini, S.
PY - 1975
Y1 - 1975
N2 - 1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.
AB - 1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.
UR - http://www.scopus.com/inward/record.url?scp=0016711968&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016711968&partnerID=8YFLogxK
U2 - 10.3109/00498257509056129
DO - 10.3109/00498257509056129
M3 - Article
C2 - 1189457
AN - SCOPUS:0016711968
VL - 5
SP - 595
EP - 600
JO - Xenobiotica
JF - Xenobiotica
SN - 0049-8254
IS - 10
ER -