Levels of piribedil and its active metabolite (s-584) in the rat striatum

R. Fanelli, A. Frigerio, S. Garattini

Research output: Contribution to journalArticle

Abstract

1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.

Original languageEnglish
Pages (from-to)595-600
Number of pages6
JournalXenobiotica
Volume5
Issue number10
DOIs
Publication statusPublished - 1975

Fingerprint

Piribedil
Metabolites
Rats
1-(2-pyrimidyl)-4-(3,4-dihydroxybenzyl)piperazine
Diazepam
Gas Chromatography
Ether
Gases
Gas chromatography
Tissue

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology
  • Biochemistry
  • Health, Toxicology and Mutagenesis
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Levels of piribedil and its active metabolite (s-584) in the rat striatum. / Fanelli, R.; Frigerio, A.; Garattini, S.

In: Xenobiotica, Vol. 5, No. 10, 1975, p. 595-600.

Research output: Contribution to journalArticle

Fanelli, R. ; Frigerio, A. ; Garattini, S. / Levels of piribedil and its active metabolite (s-584) in the rat striatum. In: Xenobiotica. 1975 ; Vol. 5, No. 10. pp. 595-600.
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