Abstract
1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.
| Original language | English |
|---|---|
| Pages (from-to) | 595-600 |
| Number of pages | 6 |
| Journal | Xenobiotica |
| Volume | 5 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1975 |
ASJC Scopus subject areas
- Pharmacology
- Toxicology
- Biochemistry
- Health, Toxicology and Mutagenesis
- Biochemistry, Genetics and Molecular Biology(all)
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Fanelli, R., Frigerio, A., & Garattini, S. (1975). Levels of piribedil and its active metabolite (s-584) in the rat striatum. Xenobiotica, 5(10), 595-600. https://doi.org/10.3109/00498257509056129