Levels of piribedil and its active metabolite (s-584) in the rat striatum

R. Fanelli, A. Frigerio, S. Garattini

Research output: Contribution to journalArticlepeer-review


1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.

Original languageEnglish
Pages (from-to)595-600
Number of pages6
Issue number10
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology
  • Biochemistry
  • Health, Toxicology and Mutagenesis
  • Biochemistry, Genetics and Molecular Biology(all)


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