Levels of piribedil and its active metabolite (s-584) in the rat striatum

R. Fanelli; A. Frigerio; S. Garattini

doi:10.3109/00498257509056129

Levels of piribedil and its active metabolite (s-584) in the rat striatum

R. Fanelli, A. Frigerio, S. Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.

Original language	English
Pages (from-to)	595-600
Number of pages	6
Journal	Xenobiotica
Volume	5
Issue number	10
DOIs	https://doi.org/10.3109/00498257509056129
Publication status	Published - 1975

ASJC Scopus subject areas

Pharmacology
Toxicology
Biochemistry
Health, Toxicology and Mutagenesis
Biochemistry, Genetics and Molecular Biology(all)

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abstract = "1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.",

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N2 - 1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.

AB - 1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.

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Levels of piribedil and its active metabolite (s-584) in the rat striatum

Abstract

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