TY - JOUR
T1 - Levels of plasma homocysteine in pseudoexfoliation glaucoma
AU - Tranchina, Laura
AU - Centofanti, Marco
AU - Oddone, Francesco
AU - Tanga, Lucia
AU - Roberti, Gloria
AU - Liberatoscioli, Laura
AU - Cortese, Claudio
AU - Manni, Gianluca
PY - 2011/3
Y1 - 2011/3
N2 - Background: To examine levels of serum homocysteine (Hcy), vitamin B12 and folic acid in patients with pseudoexfoliation glaucoma (PEXG), primary open-angle glaucoma (POAG), and healthy control subjects. Methods: This study included 36 patients with PEXG, 40 with POAG, and 40 age-matched healthy subjects. Fasting plasma Hcy concentrations and levels of serum vitamin B12 and folic acid were measured using competitive chemiluminescent enzyme immunoassay; values exceeding 14 μm/l were considered elevated. Results: Mean plasma Hcy was significantly higher in PEXG (16.55±7.23 μm/l) compared with POAG (13.91±3.61 μm/l) and controls (13.12±5.13 μm/l) (p=0.03 and p=0.0007 respectively). There were no statistical differences in serum vitamin B12 and folic acid levels among PEXG, POAG and control subjects (p>0.05). A moderate, although statistically significant, relationship between Hcy and folic acid levels was found in the PEXG group (R2=0.23, p=0.003). Hcy levels were found not to be related with folic acid or vitamin B12 in either POAG or control subjects. Conclusions: In this study, plasma Hcy is significantly higher in PEXG group than the POAG and control groups. Hyper-Hcy might play a role in the pathogenesis of PEXG. Hyper-Hcy may be an independent factor stressing vasculopathy in addition to pseudoexfoliation, so might be a modifiable risk factor for PEXG.
AB - Background: To examine levels of serum homocysteine (Hcy), vitamin B12 and folic acid in patients with pseudoexfoliation glaucoma (PEXG), primary open-angle glaucoma (POAG), and healthy control subjects. Methods: This study included 36 patients with PEXG, 40 with POAG, and 40 age-matched healthy subjects. Fasting plasma Hcy concentrations and levels of serum vitamin B12 and folic acid were measured using competitive chemiluminescent enzyme immunoassay; values exceeding 14 μm/l were considered elevated. Results: Mean plasma Hcy was significantly higher in PEXG (16.55±7.23 μm/l) compared with POAG (13.91±3.61 μm/l) and controls (13.12±5.13 μm/l) (p=0.03 and p=0.0007 respectively). There were no statistical differences in serum vitamin B12 and folic acid levels among PEXG, POAG and control subjects (p>0.05). A moderate, although statistically significant, relationship between Hcy and folic acid levels was found in the PEXG group (R2=0.23, p=0.003). Hcy levels were found not to be related with folic acid or vitamin B12 in either POAG or control subjects. Conclusions: In this study, plasma Hcy is significantly higher in PEXG group than the POAG and control groups. Hyper-Hcy might play a role in the pathogenesis of PEXG. Hyper-Hcy may be an independent factor stressing vasculopathy in addition to pseudoexfoliation, so might be a modifiable risk factor for PEXG.
KW - Homocysteine
KW - Hyperhomocysteinemia
KW - Pseudoexfoliation glaucoma
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U2 - 10.1007/s00417-010-1487-6
DO - 10.1007/s00417-010-1487-6
M3 - Article
C2 - 20740289
AN - SCOPUS:79955589539
VL - 249
SP - 443
EP - 448
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
SN - 0721-832X
IS - 3
ER -