Levels of uric acid in erectile dysfunction of different aetiology

Alessandra Barassi, Massimiliano Marco Corsi Romanelli, Raffaele Pezzilli, Elena Dozio, Clara Anna Linda Damele, Liborio Vaccalluzzo, Marco Di Dario, Giancarlo Goi, Nadia Papini, Luca Massaccesi, Giovanni Maria Colpi, Gian Vico Melzi d’Eril

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Erectile dysfunction is a common disease characterized by endothelial dysfunction. The aetiology of ED is often multifactorial but evidence is being accumulated in favor of the proper function of the vascular endothelium that is essential to achieving and maintaining penile erection. Uric acid itself causes endothelial dysfunction via decreased nitric oxide production. This study aims to evaluate the serum uric acid (SUA) levels in 180 ED patients, diagnosed with the International Index of Erectile Function-5 (IIEF-5) and 30 non-ED control. Serum uric acid was analyzed with a commercially available kit using ModularEVO (Roche, Monza, Italy). Within-assay and between-assay variations were 3.0% and 6.0%, respectively. Out of the ED patients, 85 were classified as arteriogenic (A-ED) and 95 as non-arteriogenic (NA-ED) with penile-echo-color-Doppler. Uric acid levels (median and range in mg/dL) in A-ED patients (5.8, 4.3–7.5) were significantly higher (p <.001) than in NA-ED patients (4.4, 2.6–5.9) and in control group (4.6, 3.1–7.2). There was a significant difference (p <.001) between uric acid levels in patients with mild A-ED (IIEF-5 16–20) and severe/complete A-ED (IIEF-5 ≤ 10) that were 5.4 (range 4.3–6.5) mg/dL and 6.8 (range 6.4–7.2) mg/dL, respectively. There was no difference between the levels of uric acid in patients with different degree of NA-ED. Our findings reveal that SUA is a marker of ED but only of ED of arteriogenic aetiology.

Original languageEnglish
Pages (from-to)200-205
Number of pages6
JournalAging Male
Volume21
Issue number3
DOIs
Publication statusPublished - Jul 3 2018

Fingerprint

Erectile Dysfunction
Uric Acid
Serum
Penile Erection
Vascular Endothelium
Italy
Nitric Oxide
Color
Control Groups

Keywords

  • aging and uric acid
  • Endothelial dysfunction
  • erectile dysfunction

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Barassi, A., Corsi Romanelli, M. M., Pezzilli, R., Dozio, E., Damele, C. A. L., Vaccalluzzo, L., ... Melzi d’Eril, G. V. (2018). Levels of uric acid in erectile dysfunction of different aetiology. Aging Male, 21(3), 200-205. https://doi.org/10.1080/13685538.2017.1420158

Levels of uric acid in erectile dysfunction of different aetiology. / Barassi, Alessandra; Corsi Romanelli, Massimiliano Marco; Pezzilli, Raffaele; Dozio, Elena; Damele, Clara Anna Linda; Vaccalluzzo, Liborio; Di Dario, Marco; Goi, Giancarlo; Papini, Nadia; Massaccesi, Luca; Colpi, Giovanni Maria; Melzi d’Eril, Gian Vico.

In: Aging Male, Vol. 21, No. 3, 03.07.2018, p. 200-205.

Research output: Contribution to journalArticle

Barassi, A, Corsi Romanelli, MM, Pezzilli, R, Dozio, E, Damele, CAL, Vaccalluzzo, L, Di Dario, M, Goi, G, Papini, N, Massaccesi, L, Colpi, GM & Melzi d’Eril, GV 2018, 'Levels of uric acid in erectile dysfunction of different aetiology', Aging Male, vol. 21, no. 3, pp. 200-205. https://doi.org/10.1080/13685538.2017.1420158
Barassi, Alessandra ; Corsi Romanelli, Massimiliano Marco ; Pezzilli, Raffaele ; Dozio, Elena ; Damele, Clara Anna Linda ; Vaccalluzzo, Liborio ; Di Dario, Marco ; Goi, Giancarlo ; Papini, Nadia ; Massaccesi, Luca ; Colpi, Giovanni Maria ; Melzi d’Eril, Gian Vico. / Levels of uric acid in erectile dysfunction of different aetiology. In: Aging Male. 2018 ; Vol. 21, No. 3. pp. 200-205.
@article{dda3f9cd7e8c4a51a92a60a276890618,
title = "Levels of uric acid in erectile dysfunction of different aetiology",
abstract = "Erectile dysfunction is a common disease characterized by endothelial dysfunction. The aetiology of ED is often multifactorial but evidence is being accumulated in favor of the proper function of the vascular endothelium that is essential to achieving and maintaining penile erection. Uric acid itself causes endothelial dysfunction via decreased nitric oxide production. This study aims to evaluate the serum uric acid (SUA) levels in 180 ED patients, diagnosed with the International Index of Erectile Function-5 (IIEF-5) and 30 non-ED control. Serum uric acid was analyzed with a commercially available kit using ModularEVO (Roche, Monza, Italy). Within-assay and between-assay variations were 3.0{\%} and 6.0{\%}, respectively. Out of the ED patients, 85 were classified as arteriogenic (A-ED) and 95 as non-arteriogenic (NA-ED) with penile-echo-color-Doppler. Uric acid levels (median and range in mg/dL) in A-ED patients (5.8, 4.3–7.5) were significantly higher (p <.001) than in NA-ED patients (4.4, 2.6–5.9) and in control group (4.6, 3.1–7.2). There was a significant difference (p <.001) between uric acid levels in patients with mild A-ED (IIEF-5 16–20) and severe/complete A-ED (IIEF-5 ≤ 10) that were 5.4 (range 4.3–6.5) mg/dL and 6.8 (range 6.4–7.2) mg/dL, respectively. There was no difference between the levels of uric acid in patients with different degree of NA-ED. Our findings reveal that SUA is a marker of ED but only of ED of arteriogenic aetiology.",
keywords = "aging and uric acid, Endothelial dysfunction, erectile dysfunction",
author = "Alessandra Barassi and {Corsi Romanelli}, {Massimiliano Marco} and Raffaele Pezzilli and Elena Dozio and Damele, {Clara Anna Linda} and Liborio Vaccalluzzo and {Di Dario}, Marco and Giancarlo Goi and Nadia Papini and Luca Massaccesi and Colpi, {Giovanni Maria} and {Melzi d’Eril}, {Gian Vico}",
year = "2018",
month = "7",
day = "3",
doi = "10.1080/13685538.2017.1420158",
language = "English",
volume = "21",
pages = "200--205",
journal = "Aging Male",
issn = "1368-5538",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Levels of uric acid in erectile dysfunction of different aetiology

AU - Barassi, Alessandra

AU - Corsi Romanelli, Massimiliano Marco

AU - Pezzilli, Raffaele

AU - Dozio, Elena

AU - Damele, Clara Anna Linda

AU - Vaccalluzzo, Liborio

AU - Di Dario, Marco

AU - Goi, Giancarlo

AU - Papini, Nadia

AU - Massaccesi, Luca

AU - Colpi, Giovanni Maria

AU - Melzi d’Eril, Gian Vico

PY - 2018/7/3

Y1 - 2018/7/3

N2 - Erectile dysfunction is a common disease characterized by endothelial dysfunction. The aetiology of ED is often multifactorial but evidence is being accumulated in favor of the proper function of the vascular endothelium that is essential to achieving and maintaining penile erection. Uric acid itself causes endothelial dysfunction via decreased nitric oxide production. This study aims to evaluate the serum uric acid (SUA) levels in 180 ED patients, diagnosed with the International Index of Erectile Function-5 (IIEF-5) and 30 non-ED control. Serum uric acid was analyzed with a commercially available kit using ModularEVO (Roche, Monza, Italy). Within-assay and between-assay variations were 3.0% and 6.0%, respectively. Out of the ED patients, 85 were classified as arteriogenic (A-ED) and 95 as non-arteriogenic (NA-ED) with penile-echo-color-Doppler. Uric acid levels (median and range in mg/dL) in A-ED patients (5.8, 4.3–7.5) were significantly higher (p <.001) than in NA-ED patients (4.4, 2.6–5.9) and in control group (4.6, 3.1–7.2). There was a significant difference (p <.001) between uric acid levels in patients with mild A-ED (IIEF-5 16–20) and severe/complete A-ED (IIEF-5 ≤ 10) that were 5.4 (range 4.3–6.5) mg/dL and 6.8 (range 6.4–7.2) mg/dL, respectively. There was no difference between the levels of uric acid in patients with different degree of NA-ED. Our findings reveal that SUA is a marker of ED but only of ED of arteriogenic aetiology.

AB - Erectile dysfunction is a common disease characterized by endothelial dysfunction. The aetiology of ED is often multifactorial but evidence is being accumulated in favor of the proper function of the vascular endothelium that is essential to achieving and maintaining penile erection. Uric acid itself causes endothelial dysfunction via decreased nitric oxide production. This study aims to evaluate the serum uric acid (SUA) levels in 180 ED patients, diagnosed with the International Index of Erectile Function-5 (IIEF-5) and 30 non-ED control. Serum uric acid was analyzed with a commercially available kit using ModularEVO (Roche, Monza, Italy). Within-assay and between-assay variations were 3.0% and 6.0%, respectively. Out of the ED patients, 85 were classified as arteriogenic (A-ED) and 95 as non-arteriogenic (NA-ED) with penile-echo-color-Doppler. Uric acid levels (median and range in mg/dL) in A-ED patients (5.8, 4.3–7.5) were significantly higher (p <.001) than in NA-ED patients (4.4, 2.6–5.9) and in control group (4.6, 3.1–7.2). There was a significant difference (p <.001) between uric acid levels in patients with mild A-ED (IIEF-5 16–20) and severe/complete A-ED (IIEF-5 ≤ 10) that were 5.4 (range 4.3–6.5) mg/dL and 6.8 (range 6.4–7.2) mg/dL, respectively. There was no difference between the levels of uric acid in patients with different degree of NA-ED. Our findings reveal that SUA is a marker of ED but only of ED of arteriogenic aetiology.

KW - aging and uric acid

KW - Endothelial dysfunction

KW - erectile dysfunction

UR - http://www.scopus.com/inward/record.url?scp=85041109056&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041109056&partnerID=8YFLogxK

U2 - 10.1080/13685538.2017.1420158

DO - 10.1080/13685538.2017.1420158

M3 - Article

C2 - 29327639

AN - SCOPUS:85041109056

VL - 21

SP - 200

EP - 205

JO - Aging Male

JF - Aging Male

SN - 1368-5538

IS - 3

ER -