Levetiracetam affects differentially presynaptic proteins in rat cerebral cortex

Daniele Marcotulli, Giorgia Fattorini, Luca Bragina, Jessica Perugini, Fiorenzo Conti

Research output: Contribution to journalArticlepeer-review

Abstract

Presynaptic proteins are potential therapeutic targets for epilepsy and other neurological diseases. We tested the hypothesis that chronic treatment with the SV2A ligand levetiracetam affects the expression of other presynaptic proteins. Results showed that in rat neocortex no significant difference was detected in SV2A protein levels in levetiracetam treated animals compared to controls, whereas levetiracetam posttranscriptionally decreased several vesicular proteins and increased LRRK2, without any change in mRNA levels. Analysis of SV2A interactome indicates that the presynaptic proteins regulation induced by levetiracetam reported here is mediated by this interactome, and suggests that LRRK2 plays a role in forging the pattern of effects.

Original languageEnglish
Article number389
JournalFrontiers in Cellular Neuroscience
Volume11
DOIs
Publication statusPublished - Dec 11 2017

Keywords

  • Interactome
  • Levetiracetam
  • LRRK2
  • Presynaptic proteins
  • SV2A
  • Vesicular transport proteins

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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