Levetiracetam clinical pharmacokinetics in elderly and very elderly patients with epilepsy

M. Contin; S. Mohamed; F. Albani; R. Riva; A. Baruzzi

doi:10.1016/j.eplepsyres.2011.08.020

Levetiracetam clinical pharmacokinetics in elderly and very elderly patients with epilepsy

M. Contin, S. Mohamed, F. Albani, R. Riva, A. Baruzzi

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

We aimed to compare apparent steady-state oral clearance (CL/F) of the antiepileptic drug levetiracetam (LEV) in elderly (66-80 years, n=105) and very elderly (81-96 years, n=70) vs nonelderly (30-65 years, n=97) patients with epilepsy. Median weight-normalized CL/F (mLmin ^-1kg ^-1) decreased from 1.23 (nonelderly) to 0.83 (elderly) and 0.59 (very elderly) (p

Original language	English
Pages (from-to)	130-134
Number of pages	5
Journal	Epilepsy Research
Volume	98
Issue number	2-3
DOIs	https://doi.org/10.1016/j.eplepsyres.2011.08.020
Publication status	Published - Feb 2012

Keywords

Elderly and very elderly patients
Levetiracetam
Oral clearance
Pharmacokinetics
Therapeutic drug monitoring

ASJC Scopus subject areas

Clinical Neurology
Neurology

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title = "Levetiracetam clinical pharmacokinetics in elderly and very elderly patients with epilepsy",

abstract = "We aimed to compare apparent steady-state oral clearance (CL/F) of the antiepileptic drug levetiracetam (LEV) in elderly (66-80 years, n=105) and very elderly (81-96 years, n=70) vs nonelderly (30-65 years, n=97) patients with epilepsy. Median weight-normalized CL/F (mLmin -1kg -1) decreased from 1.23 (nonelderly) to 0.83 (elderly) and 0.59 (very elderly) (p",

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AU - Contin, M.

AU - Mohamed, S.

AU - Albani, F.

AU - Riva, R.

AU - Baruzzi, A.

PY - 2012/2

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AB - We aimed to compare apparent steady-state oral clearance (CL/F) of the antiepileptic drug levetiracetam (LEV) in elderly (66-80 years, n=105) and very elderly (81-96 years, n=70) vs nonelderly (30-65 years, n=97) patients with epilepsy. Median weight-normalized CL/F (mLmin -1kg -1) decreased from 1.23 (nonelderly) to 0.83 (elderly) and 0.59 (very elderly) (p

KW - Elderly and very elderly patients

KW - Levetiracetam

KW - Oral clearance

KW - Pharmacokinetics

KW - Therapeutic drug monitoring

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