Levetiracetam clinical pharmacokinetics in elderly and very elderly patients with epilepsy

M. Contin, S. Mohamed, F. Albani, R. Riva, A. Baruzzi

Research output: Contribution to journalArticle

Abstract

We aimed to compare apparent steady-state oral clearance (CL/F) of the antiepileptic drug levetiracetam (LEV) in elderly (66-80 years, n=105) and very elderly (81-96 years, n=70) vs nonelderly (30-65 years, n=97) patients with epilepsy. Median weight-normalized CL/F (mLmin -1kg -1) decreased from 1.23 (nonelderly) to 0.83 (elderly) and 0.59 (very elderly) (p

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalEpilepsy Research
Volume98
Issue number2-3
DOIs
Publication statusPublished - Feb 2012

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Keywords

  • Elderly and very elderly patients
  • Levetiracetam
  • Oral clearance
  • Pharmacokinetics
  • Therapeutic drug monitoring

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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