Levocetirizine improves nasal symptoms and airflow in patients with persistent allergic rhinitis: A pilot study

G. Ciprandi, I. G. Cirillo, A. Vizzaccaro, M. A. Tosca

Research output: Contribution to journalArticle

Abstract

Background: Nasal obstruction is the main symptom in patients with persistent allergic rhinitis. Some antihistamines have been demonstrated to be capable of improving this symptom. The aim of this pilot study was to evaluate nasal symptoms, nasal airflow, and decongestent activity in patients with persistent allergic rhinitis, before and after treatment with levocetirizine or placebo. Methods: Forty patients with persistent allergic rhinitis were evaluated, 35 males and 5 females (mean age 23.3 + 5.9 years). All of them received levocetirizine (5 mg/daily) or placebo for 4 weeks. The study was double-blind, parallel-group, placebo-controlled, and randomized. Total symptom score (including: nasal itching, sneezing, rhinorrhea, and nasal obstruction) was assessed before and after treatment. Rhinomanometry and decongestion test were performed in all subjects before and after treatment. Results: Levocetirizine treatment induced: significant symptom relief (p

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalEuropean Annals of Allergy and Clinical Immunology
Volume37
Issue number1
Publication statusPublished - Jan 2005

Fingerprint

Nose
Nasal Obstruction
Placebos
Rhinomanometry
Sneezing
Histamine Antagonists
Therapeutics
Pruritus
Double-Blind Method
levocetirizine
Allergic Rhinitis

Keywords

  • Decongestion test
  • Levocetirizine
  • Nasal airflow
  • Nasal obstruction
  • Persistent allergic rhinitis
  • Rhinomanometry

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Levocetirizine improves nasal symptoms and airflow in patients with persistent allergic rhinitis : A pilot study. / Ciprandi, G.; Cirillo, I. G.; Vizzaccaro, A.; Tosca, M. A.

In: European Annals of Allergy and Clinical Immunology, Vol. 37, No. 1, 01.2005, p. 25-29.

Research output: Contribution to journalArticle

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