Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter Fuhr & 19 others Ute Gschwandtner, Gerhard Ransmayr, Lucia Fraioli, Lucilla Parnetti, Lucia Farotti, Michela Pievani, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, John Paul Taylor, Ian McKeith, Fabrizio Stocchi, Laura Vacca, Giovanni B. Frisoni, Maria Francesca De Pandis

Research output: Contribution to journalArticle

Abstract

We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8–12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (<4 Hz) sources. Widespread frontal and temporal alpha sources exhibited an increase in PD with dementia compared with PD with mild cognitive impairment and PD with normal cognition groups, as function of dopamine depletion severity, typically greater in the former than the latter groups. A daily dose of levodopa induced a widespread reduction in cortical delta and alpha sources in a subgroup of 13 PD patients under standard chronic dopaminergic regimen. In PD patients in quiet wakefulness, alpha cortical source activations may reflect an excitatory effect of dopamine neuromodulation.

LanguageEnglish
Pages9-20
Number of pages12
JournalNeurobiology of Aging
Volume73
DOIs
Publication statusPublished - Jan 1 2019

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Levodopa
Parkinson Disease
Dopamine
Wakefulness
Cognition
Dementia
Alpha Rhythm
Cortical Excitability
Electromagnetic Phenomena
Tomography
Brain

Keywords

  • Functional brain connectivity
  • Mild cognitive impairment due to Alzheimer's disease (ADMCI)
  • Mild cognitive impairment due to Parkinson's disease (PDMCI)
  • Resting state EEG rhythms

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms. / Babiloni, Claudio; Del Percio, Claudio; Lizio, Roberta; Noce, Giuseppe; Lopez, Susanna; Soricelli, Andrea; Ferri, Raffaele; Pascarelli, Maria Teresa; Catania, Valentina; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Bonanni, Laura; Franciotti, Raffaella; Onofrj, Marco; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Fraioli, Lucia; Parnetti, Lucilla; Farotti, Lucia; Pievani, Michela; D'Antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Hanoğlu, Lutfu; Yener, Görsev; Emek-Savaş, Derya Durusu; Triggiani, Antonio Ivano; Taylor, John Paul; McKeith, Ian; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B.; De Pandis, Maria Francesca.

In: Neurobiology of Aging, Vol. 73, 01.01.2019, p. 9-20.

Research output: Contribution to journalArticle

Babiloni, C, Del Percio, C, Lizio, R, Noce, G, Lopez, S, Soricelli, A, Ferri, R, Pascarelli, MT, Catania, V, Nobili, F, Arnaldi, D, Famà, F, Orzi, F, Buttinelli, C, Giubilei, F, Bonanni, L, Franciotti, R, Onofrj, M, Stirpe, P, Fuhr, P, Gschwandtner, U, Ransmayr, G, Fraioli, L, Parnetti, L, Farotti, L, Pievani, M, D'Antonio, F, De Lena, C, Güntekin, B, Hanoğlu, L, Yener, G, Emek-Savaş, DD, Triggiani, AI, Taylor, JP, McKeith, I, Stocchi, F, Vacca, L, Frisoni, GB & De Pandis, MF 2019, 'Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms' Neurobiology of Aging, vol. 73, pp. 9-20. https://doi.org/10.1016/j.neurobiolaging.2018.08.010
Babiloni, Claudio ; Del Percio, Claudio ; Lizio, Roberta ; Noce, Giuseppe ; Lopez, Susanna ; Soricelli, Andrea ; Ferri, Raffaele ; Pascarelli, Maria Teresa ; Catania, Valentina ; Nobili, Flavio ; Arnaldi, Dario ; Famà, Francesco ; Orzi, Francesco ; Buttinelli, Carla ; Giubilei, Franco ; Bonanni, Laura ; Franciotti, Raffaella ; Onofrj, Marco ; Stirpe, Paola ; Fuhr, Peter ; Gschwandtner, Ute ; Ransmayr, Gerhard ; Fraioli, Lucia ; Parnetti, Lucilla ; Farotti, Lucia ; Pievani, Michela ; D'Antonio, Fabrizia ; De Lena, Carlo ; Güntekin, Bahar ; Hanoğlu, Lutfu ; Yener, Görsev ; Emek-Savaş, Derya Durusu ; Triggiani, Antonio Ivano ; Taylor, John Paul ; McKeith, Ian ; Stocchi, Fabrizio ; Vacca, Laura ; Frisoni, Giovanni B. ; De Pandis, Maria Francesca. / Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms. In: Neurobiology of Aging. 2019 ; Vol. 73. pp. 9-20.
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AU - Babiloni, Claudio

AU - Del Percio, Claudio

AU - Lizio, Roberta

AU - Noce, Giuseppe

AU - Lopez, Susanna

AU - Soricelli, Andrea

AU - Ferri, Raffaele

AU - Pascarelli, Maria Teresa

AU - Catania, Valentina

AU - Nobili, Flavio

AU - Arnaldi, Dario

AU - Famà, Francesco

AU - Orzi, Francesco

AU - Buttinelli, Carla

AU - Giubilei, Franco

AU - Bonanni, Laura

AU - Franciotti, Raffaella

AU - Onofrj, Marco

AU - Stirpe, Paola

AU - Fuhr, Peter

AU - Gschwandtner, Ute

AU - Ransmayr, Gerhard

AU - Fraioli, Lucia

AU - Parnetti, Lucilla

AU - Farotti, Lucia

AU - Pievani, Michela

AU - D'Antonio, Fabrizia

AU - De Lena, Carlo

AU - Güntekin, Bahar

AU - Hanoğlu, Lutfu

AU - Yener, Görsev

AU - Emek-Savaş, Derya Durusu

AU - Triggiani, Antonio Ivano

AU - Taylor, John Paul

AU - McKeith, Ian

AU - Stocchi, Fabrizio

AU - Vacca, Laura

AU - Frisoni, Giovanni B.

AU - De Pandis, Maria Francesca

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