Abstract
We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (<4 Hz) sources. Widespread frontal and temporal alpha sources exhibited an increase in PD with dementia compared with PD with mild cognitive impairment and PD with normal cognition groups, as function of dopamine depletion severity, typically greater in the former than the latter groups. A daily dose of levodopa induced a widespread reduction in cortical delta and alpha sources in a subgroup of 13 PD patients under standard chronic dopaminergic regimen. In PD patients in quiet wakefulness, alpha cortical source activations may reflect an excitatory effect of dopamine neuromodulation.
| Original language | English |
|---|---|
| Pages (from-to) | 9-20 |
| Number of pages | 12 |
| Journal | Neurobiology of Aging |
| Volume | 73 |
| DOIs | |
| Publication status | E-pub ahead of print - Aug 30 2018 |
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Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms. / Babiloni, Claudio; Del Percio, Claudio; Lizio, Roberta; Noce, Giuseppe; Lopez, Susanna; Soricelli, Andrea; Ferri, Raffaele; Pascarelli, Maria Teresa; Catania, Valentina; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Bonanni, Laura; Franciotti, Raffaella; Onofrj, Marco; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Fraioli, Lucia; Parnetti, Lucilla; Farotti, Lucia; Pievani, Michela; D'Antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Hanoğlu, Lutfu; Yener, Görsev; Emek-Savaş, Derya Durusu; Triggiani, Antonio Ivano; Taylor, John Paul; McKeith, Ian; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B; De Pandis, Maria Francesca.
In: Neurobiology of Aging, Vol. 73, 30.08.2018, p. 9-20.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms
AU - Babiloni, Claudio
AU - Del Percio, Claudio
AU - Lizio, Roberta
AU - Noce, Giuseppe
AU - Lopez, Susanna
AU - Soricelli, Andrea
AU - Ferri, Raffaele
AU - Pascarelli, Maria Teresa
AU - Catania, Valentina
AU - Nobili, Flavio
AU - Arnaldi, Dario
AU - Famà, Francesco
AU - Orzi, Francesco
AU - Buttinelli, Carla
AU - Giubilei, Franco
AU - Bonanni, Laura
AU - Franciotti, Raffaella
AU - Onofrj, Marco
AU - Stirpe, Paola
AU - Fuhr, Peter
AU - Gschwandtner, Ute
AU - Ransmayr, Gerhard
AU - Fraioli, Lucia
AU - Parnetti, Lucilla
AU - Farotti, Lucia
AU - Pievani, Michela
AU - D'Antonio, Fabrizia
AU - De Lena, Carlo
AU - Güntekin, Bahar
AU - Hanoğlu, Lutfu
AU - Yener, Görsev
AU - Emek-Savaş, Derya Durusu
AU - Triggiani, Antonio Ivano
AU - Taylor, John Paul
AU - McKeith, Ian
AU - Stocchi, Fabrizio
AU - Vacca, Laura
AU - Frisoni, Giovanni B
AU - De Pandis, Maria Francesca
N1 - Copyright © 2018 Elsevier Inc. All rights reserved.
PY - 2018/8/30
Y1 - 2018/8/30
N2 - We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (<4 Hz) sources. Widespread frontal and temporal alpha sources exhibited an increase in PD with dementia compared with PD with mild cognitive impairment and PD with normal cognition groups, as function of dopamine depletion severity, typically greater in the former than the latter groups. A daily dose of levodopa induced a widespread reduction in cortical delta and alpha sources in a subgroup of 13 PD patients under standard chronic dopaminergic regimen. In PD patients in quiet wakefulness, alpha cortical source activations may reflect an excitatory effect of dopamine neuromodulation.
AB - We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (<4 Hz) sources. Widespread frontal and temporal alpha sources exhibited an increase in PD with dementia compared with PD with mild cognitive impairment and PD with normal cognition groups, as function of dopamine depletion severity, typically greater in the former than the latter groups. A daily dose of levodopa induced a widespread reduction in cortical delta and alpha sources in a subgroup of 13 PD patients under standard chronic dopaminergic regimen. In PD patients in quiet wakefulness, alpha cortical source activations may reflect an excitatory effect of dopamine neuromodulation.
U2 - 10.1016/j.neurobiolaging.2018.08.010
DO - 10.1016/j.neurobiolaging.2018.08.010
M3 - Article
C2 - 30312790
VL - 73
SP - 9
EP - 20
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -