Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

C. Babiloni, C. Del Percio, R. Lizio, G. Noce, S. Lopez, A. Soricelli, R. Ferri, M.T. Pascarelli, V. Catania, F. Nobili, D. Arnaldi, F. Famà, F. Orzi, C. Buttinelli, F. Giubilei, L. Bonanni, R. Franciotti, M. Onofrj, P. Stirpe, P. FuhrU. Gschwandtner, G. Ransmayr, L. Fraioli, L. Parnetti, L. Farotti, M. Pievani, F. D'Antonio, C. De Lena, B. Güntekin, L. Hanoğlu, G. Yener, D.D. Emek-Savaş, A.I. Triggiani, J.P. Taylor, I. McKeith, F. Stocchi, L. Vacca, G.B. Frisoni, M.F. De Pandis

Research output: Contribution to journalArticle

Abstract

We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8–12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (
Original languageEnglish
Pages (from-to)9-20
Number of pages12
JournalNeurobiology of Aging
Volume73
DOIs
Publication statusE-pub ahead of print - Aug 30 2018

Fingerprint

Levodopa
Parkinson Disease
Alpha Rhythm
Wakefulness
Electromagnetic Phenomena
Cognition
Dementia
Dopamine
Tomography
Cortical Excitability
Brain

Keywords

  • Functional brain connectivity
  • Mild cognitive impairment due to Alzheimer's disease (ADMCI)
  • Mild cognitive impairment due to Parkinson's disease (PDMCI)
  • Resting state EEG rhythms
  • amantadine
  • benserazide
  • carbidopa
  • dopamine
  • entacapone
  • levodopa
  • pramipexole
  • ropinirole
  • rotigotine
  • selegiline
  • aged
  • alpha rhythm
  • Article
  • clinical feature
  • cognition
  • cognitive defect
  • comparative study
  • controlled study
  • cortical excitability
  • delta rhythm
  • dementia
  • electroencephalography
  • female
  • frontal cortex
  • human
  • low resolution brain electromagnetic tomography
  • major clinical study
  • male
  • mild cognitive impairment
  • neuromodulation
  • occipital cortex
  • Parkinson disease
  • priority journal
  • rest
  • temporal cortex
  • wakefulness

Cite this

Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms. / Babiloni, C.; Del Percio, C.; Lizio, R.; Noce, G.; Lopez, S.; Soricelli, A.; Ferri, R.; Pascarelli, M.T.; Catania, V.; Nobili, F.; Arnaldi, D.; Famà, F.; Orzi, F.; Buttinelli, C.; Giubilei, F.; Bonanni, L.; Franciotti, R.; Onofrj, M.; Stirpe, P.; Fuhr, P.; Gschwandtner, U.; Ransmayr, G.; Fraioli, L.; Parnetti, L.; Farotti, L.; Pievani, M.; D'Antonio, F.; De Lena, C.; Güntekin, B.; Hanoğlu, L.; Yener, G.; Emek-Savaş, D.D.; Triggiani, A.I.; Taylor, J.P.; McKeith, I.; Stocchi, F.; Vacca, L.; Frisoni, G.B.; De Pandis, M.F.

In: Neurobiology of Aging, Vol. 73, 30.08.2018, p. 9-20.

Research output: Contribution to journalArticle

Babiloni, C, Del Percio, C, Lizio, R, Noce, G, Lopez, S, Soricelli, A, Ferri, R, Pascarelli, MT, Catania, V, Nobili, F, Arnaldi, D, Famà, F, Orzi, F, Buttinelli, C, Giubilei, F, Bonanni, L, Franciotti, R, Onofrj, M, Stirpe, P, Fuhr, P, Gschwandtner, U, Ransmayr, G, Fraioli, L, Parnetti, L, Farotti, L, Pievani, M, D'Antonio, F, De Lena, C, Güntekin, B, Hanoğlu, L, Yener, G, Emek-Savaş, DD, Triggiani, AI, Taylor, JP, McKeith, I, Stocchi, F, Vacca, L, Frisoni, GB & De Pandis, MF 2018, 'Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms', Neurobiology of Aging, vol. 73, pp. 9-20. https://doi.org/10.1016/j.neurobiolaging.2018.08.010
Babiloni, C. ; Del Percio, C. ; Lizio, R. ; Noce, G. ; Lopez, S. ; Soricelli, A. ; Ferri, R. ; Pascarelli, M.T. ; Catania, V. ; Nobili, F. ; Arnaldi, D. ; Famà, F. ; Orzi, F. ; Buttinelli, C. ; Giubilei, F. ; Bonanni, L. ; Franciotti, R. ; Onofrj, M. ; Stirpe, P. ; Fuhr, P. ; Gschwandtner, U. ; Ransmayr, G. ; Fraioli, L. ; Parnetti, L. ; Farotti, L. ; Pievani, M. ; D'Antonio, F. ; De Lena, C. ; Güntekin, B. ; Hanoğlu, L. ; Yener, G. ; Emek-Savaş, D.D. ; Triggiani, A.I. ; Taylor, J.P. ; McKeith, I. ; Stocchi, F. ; Vacca, L. ; Frisoni, G.B. ; De Pandis, M.F. / Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms. In: Neurobiology of Aging. 2018 ; Vol. 73. pp. 9-20.
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title = "Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms",
abstract = "We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8–12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (",
keywords = "Functional brain connectivity, Mild cognitive impairment due to Alzheimer's disease (ADMCI), Mild cognitive impairment due to Parkinson's disease (PDMCI), Resting state EEG rhythms, amantadine, benserazide, carbidopa, dopamine, entacapone, levodopa, pramipexole, ropinirole, rotigotine, selegiline, aged, alpha rhythm, Article, clinical feature, cognition, cognitive defect, comparative study, controlled study, cortical excitability, delta rhythm, dementia, electroencephalography, female, frontal cortex, human, low resolution brain electromagnetic tomography, major clinical study, male, mild cognitive impairment, neuromodulation, occipital cortex, Parkinson disease, priority journal, rest, temporal cortex, wakefulness",
author = "C. Babiloni and {Del Percio}, C. and R. Lizio and G. Noce and S. Lopez and A. Soricelli and R. Ferri and M.T. Pascarelli and V. Catania and F. Nobili and D. Arnaldi and F. Fam{\`a} and F. Orzi and C. Buttinelli and F. Giubilei and L. Bonanni and R. Franciotti and M. Onofrj and P. Stirpe and P. Fuhr and U. Gschwandtner and G. Ransmayr and L. Fraioli and L. Parnetti and L. Farotti and M. Pievani and F. D'Antonio and {De Lena}, C. and B. G{\"u}ntekin and L. Hanoğlu and G. Yener and D.D. Emek-Savaş and A.I. Triggiani and J.P. Taylor and I. McKeith and F. Stocchi and L. Vacca and G.B. Frisoni and {De Pandis}, M.F.",
note = "Export Date: 29 January 2019 CODEN: NEAGD Correspondence Address: Babiloni, C.; Department of Physiology and Pharmacology “V. Erspamer” University of Rome “La Sapienza”, P. le A. Moro 5, Italy; email: claudio.babiloni@uniroma1.it Chemicals/CAS: amantadine, 665-66-7, 768-94-5; benserazide, 14919-77-8, 322-35-0; carbidopa, 28860-95-9, 38821-49-7; dopamine, 51-61-6, 62-31-7; entacapone, 116314-67-1; levodopa, 59-92-7; pramipexole, 104632-26-0, 104632-25-9; ropinirole, 91374-21-9; rotigotine, 92206-54-7; selegiline, 14611-51-9, 14611-52-0, 2079-54-1, 2323-36-6 Funding details: European Consortium for Political Research, ECPR Funding text 1: The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the Consortia are reported in the cover page of this article. The research activities of the Unit of University of Rome “La Sapienza” were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title “BBDiag” ( http://bbdiag-itn-etn.eu ). The authors thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project. References: Aarsland, D., Litvan, I., Salmon, D., Galasko, D., Wentzel-Larsen, T., Larsen, J.P., Performance on the dementia rating scale in Parkinson's disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer's disease (2003) J. Neurol. Neurosurg. Psychiatry, 74, pp. 1215-1220; Adamiak, U., Kaldonska, M., Klodowska-Duda, G., Wyska, E., Safranow, K., Bialecka, M., Gawronska-Szklarz, B., Pharmacokinetic-pharmacodynamic modeling of levodopa in patients with advanced Parkinson disease (2010) Clin. 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year = "2018",
month = "8",
day = "30",
doi = "10.1016/j.neurobiolaging.2018.08.010",
language = "English",
volume = "73",
pages = "9--20",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

AU - Babiloni, C.

AU - Del Percio, C.

AU - Lizio, R.

AU - Noce, G.

AU - Lopez, S.

AU - Soricelli, A.

AU - Ferri, R.

AU - Pascarelli, M.T.

AU - Catania, V.

AU - Nobili, F.

AU - Arnaldi, D.

AU - Famà, F.

AU - Orzi, F.

AU - Buttinelli, C.

AU - Giubilei, F.

AU - Bonanni, L.

AU - Franciotti, R.

AU - Onofrj, M.

AU - Stirpe, P.

AU - Fuhr, P.

AU - Gschwandtner, U.

AU - Ransmayr, G.

AU - Fraioli, L.

AU - Parnetti, L.

AU - Farotti, L.

AU - Pievani, M.

AU - D'Antonio, F.

AU - De Lena, C.

AU - Güntekin, B.

AU - Hanoğlu, L.

AU - Yener, G.

AU - Emek-Savaş, D.D.

AU - Triggiani, A.I.

AU - Taylor, J.P.

AU - McKeith, I.

AU - Stocchi, F.

AU - Vacca, L.

AU - Frisoni, G.B.

AU - De Pandis, M.F.

N1 - Export Date: 29 January 2019 CODEN: NEAGD Correspondence Address: Babiloni, C.; Department of Physiology and Pharmacology “V. Erspamer” University of Rome “La Sapienza”, P. le A. Moro 5, Italy; email: claudio.babiloni@uniroma1.it Chemicals/CAS: amantadine, 665-66-7, 768-94-5; benserazide, 14919-77-8, 322-35-0; carbidopa, 28860-95-9, 38821-49-7; dopamine, 51-61-6, 62-31-7; entacapone, 116314-67-1; levodopa, 59-92-7; pramipexole, 104632-26-0, 104632-25-9; ropinirole, 91374-21-9; rotigotine, 92206-54-7; selegiline, 14611-51-9, 14611-52-0, 2079-54-1, 2323-36-6 Funding details: European Consortium for Political Research, ECPR Funding text 1: The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the Consortia are reported in the cover page of this article. The research activities of the Unit of University of Rome “La Sapienza” were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title “BBDiag” ( http://bbdiag-itn-etn.eu ). The authors thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project. References: Aarsland, D., Litvan, I., Salmon, D., Galasko, D., Wentzel-Larsen, T., Larsen, J.P., Performance on the dementia rating scale in Parkinson's disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer's disease (2003) J. Neurol. Neurosurg. Psychiatry, 74, pp. 1215-1220; Adamiak, U., Kaldonska, M., Klodowska-Duda, G., Wyska, E., Safranow, K., Bialecka, M., Gawronska-Szklarz, B., Pharmacokinetic-pharmacodynamic modeling of levodopa in patients with advanced Parkinson disease (2010) Clin. 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PY - 2018/8/30

Y1 - 2018/8/30

N2 - We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8–12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (

AB - We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8–12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (

KW - Functional brain connectivity

KW - Mild cognitive impairment due to Alzheimer's disease (ADMCI)

KW - Mild cognitive impairment due to Parkinson's disease (PDMCI)

KW - Resting state EEG rhythms

KW - amantadine

KW - benserazide

KW - carbidopa

KW - dopamine

KW - entacapone

KW - levodopa

KW - pramipexole

KW - ropinirole

KW - rotigotine

KW - selegiline

KW - aged

KW - alpha rhythm

KW - Article

KW - clinical feature

KW - cognition

KW - cognitive defect

KW - comparative study

KW - controlled study

KW - cortical excitability

KW - delta rhythm

KW - dementia

KW - electroencephalography

KW - female

KW - frontal cortex

KW - human

KW - low resolution brain electromagnetic tomography

KW - major clinical study

KW - male

KW - mild cognitive impairment

KW - neuromodulation

KW - occipital cortex

KW - Parkinson disease

KW - priority journal

KW - rest

KW - temporal cortex

KW - wakefulness

U2 - 10.1016/j.neurobiolaging.2018.08.010

DO - 10.1016/j.neurobiolaging.2018.08.010

M3 - Article

VL - 73

SP - 9

EP - 20

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -