Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

C. Babiloni, C. Del Percio, R. Lizio, G. Noce, S. Lopez, A. Soricelli, R. Ferri, M.T. Pascarelli, V. Catania, F. Nobili, D. Arnaldi, F. Famà, F. Orzi, C. Buttinelli, F. Giubilei, L. Bonanni, R. Franciotti, M. Onofrj, P. Stirpe, P. FuhrU. Gschwandtner, G. Ransmayr, L. Fraioli, L. Parnetti, L. Farotti, M. Pievani, F. D'Antonio, C. De Lena, B. Güntekin, L. Hanoğlu, G. Yener, D.D. Emek-Savaş, A.I. Triggiani, J.P. Taylor, I. McKeith, F. Stocchi, L. Vacca, G.B. Frisoni, M.F. De Pandis

Research output: Contribution to journalArticlepeer-review

Abstract

We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8–12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (
Original languageEnglish
Pages (from-to)9-20
Number of pages12
JournalNeurobiology of Aging
Volume73
DOIs
Publication statusE-pub ahead of print - Aug 30 2018

Keywords

  • Functional brain connectivity
  • Mild cognitive impairment due to Alzheimer's disease (ADMCI)
  • Mild cognitive impairment due to Parkinson's disease (PDMCI)
  • Resting state EEG rhythms
  • amantadine
  • benserazide
  • carbidopa
  • dopamine
  • entacapone
  • levodopa
  • pramipexole
  • ropinirole
  • rotigotine
  • selegiline
  • aged
  • alpha rhythm
  • Article
  • clinical feature
  • cognition
  • cognitive defect
  • comparative study
  • controlled study
  • cortical excitability
  • delta rhythm
  • dementia
  • electroencephalography
  • female
  • frontal cortex
  • human
  • low resolution brain electromagnetic tomography
  • major clinical study
  • male
  • mild cognitive impairment
  • neuromodulation
  • occipital cortex
  • Parkinson disease
  • priority journal
  • rest
  • temporal cortex
  • wakefulness

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