Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter Fuhr & 19 others Ute Gschwandtner, Gerhard Ransmayr, Lucia Fraioli, Lucilla Parnetti, Lucia Farotti, Michela Pievani, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, John Paul Taylor, Ian McKeith, Fabrizio Stocchi, Laura Vacca, Giovanni B. Frisoni, Maria Francesca De Pandis

Research output: Contribution to journalArticle

Abstract

We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8–12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (
Original languageEnglish
Pages (from-to)9-20
Number of pages12
JournalNeurobiology of Aging
Volume73
DOIs
Publication statusE-pub ahead of print - 2018

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Levodopa
Parkinson Disease
Alpha Rhythm
Wakefulness
Electromagnetic Phenomena
Cognition
Dementia
Dopamine
Tomography
Cortical Excitability
Brain

Keywords

  • Functional brain connectivity
  • Resting state EEG rhythms
  • Mild cognitive impairment due to Alzheimer's disease (ADMCI)
  • Mild cognitive impairment due to Parkinson's disease (PDMCI)

Cite this

Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms. / Babiloni, Claudio; Del Percio, Claudio; Lizio, Roberta; Noce, Giuseppe; Lopez, Susanna; Soricelli, Andrea; Ferri, Raffaele; Pascarelli, Maria Teresa; Catania, Valentina; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Bonanni, Laura; Franciotti, Raffaella; Onofrj, Marco; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Fraioli, Lucia; Parnetti, Lucilla; Farotti, Lucia; Pievani, Michela; D'Antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Hanoğlu, Lutfu; Yener, Görsev; Emek-Savaş, Derya Durusu; Triggiani, Antonio Ivano; Taylor, John Paul; McKeith, Ian; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B.; De Pandis, Maria Francesca.

In: Neurobiology of Aging, Vol. 73, 2018, p. 9-20.

Research output: Contribution to journalArticle

Babiloni, C, Del Percio, C, Lizio, R, Noce, G, Lopez, S, Soricelli, A, Ferri, R, Pascarelli, MT, Catania, V, Nobili, F, Arnaldi, D, Famà, F, Orzi, F, Buttinelli, C, Giubilei, F, Bonanni, L, Franciotti, R, Onofrj, M, Stirpe, P, Fuhr, P, Gschwandtner, U, Ransmayr, G, Fraioli, L, Parnetti, L, Farotti, L, Pievani, M, D'Antonio, F, De Lena, C, Güntekin, B, Hanoğlu, L, Yener, G, Emek-Savaş, DD, Triggiani, AI, Taylor, JP, McKeith, I, Stocchi, F, Vacca, L, Frisoni, GB & De Pandis, MF 2018, 'Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms', Neurobiology of Aging, vol. 73, pp. 9-20. https://doi.org/10.1016/j.neurobiolaging.2018.08.010
Babiloni, Claudio ; Del Percio, Claudio ; Lizio, Roberta ; Noce, Giuseppe ; Lopez, Susanna ; Soricelli, Andrea ; Ferri, Raffaele ; Pascarelli, Maria Teresa ; Catania, Valentina ; Nobili, Flavio ; Arnaldi, Dario ; Famà, Francesco ; Orzi, Francesco ; Buttinelli, Carla ; Giubilei, Franco ; Bonanni, Laura ; Franciotti, Raffaella ; Onofrj, Marco ; Stirpe, Paola ; Fuhr, Peter ; Gschwandtner, Ute ; Ransmayr, Gerhard ; Fraioli, Lucia ; Parnetti, Lucilla ; Farotti, Lucia ; Pievani, Michela ; D'Antonio, Fabrizia ; De Lena, Carlo ; Güntekin, Bahar ; Hanoğlu, Lutfu ; Yener, Görsev ; Emek-Savaş, Derya Durusu ; Triggiani, Antonio Ivano ; Taylor, John Paul ; McKeith, Ian ; Stocchi, Fabrizio ; Vacca, Laura ; Frisoni, Giovanni B. ; De Pandis, Maria Francesca. / Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms. In: Neurobiology of Aging. 2018 ; Vol. 73. pp. 9-20.
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T1 - Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

AU - Babiloni, Claudio

AU - Del Percio, Claudio

AU - Lizio, Roberta

AU - Noce, Giuseppe

AU - Lopez, Susanna

AU - Soricelli, Andrea

AU - Ferri, Raffaele

AU - Pascarelli, Maria Teresa

AU - Catania, Valentina

AU - Nobili, Flavio

AU - Arnaldi, Dario

AU - Famà, Francesco

AU - Orzi, Francesco

AU - Buttinelli, Carla

AU - Giubilei, Franco

AU - Bonanni, Laura

AU - Franciotti, Raffaella

AU - Onofrj, Marco

AU - Stirpe, Paola

AU - Fuhr, Peter

AU - Gschwandtner, Ute

AU - Ransmayr, Gerhard

AU - Fraioli, Lucia

AU - Parnetti, Lucilla

AU - Farotti, Lucia

AU - Pievani, Michela

AU - D'Antonio, Fabrizia

AU - De Lena, Carlo

AU - Güntekin, Bahar

AU - Hanoğlu, Lutfu

AU - Yener, Görsev

AU - Emek-Savaş, Derya Durusu

AU - Triggiani, Antonio Ivano

AU - Taylor, John Paul

AU - McKeith, Ian

AU - Stocchi, Fabrizio

AU - Vacca, Laura

AU - Frisoni, Giovanni B.

AU - De Pandis, Maria Francesca

PY - 2018

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AB - We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8–12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (

KW - Functional brain connectivity

KW - Resting state EEG rhythms

KW - Mild cognitive impairment due to Alzheimer's disease (ADMCI)

KW - Mild cognitive impairment due to Parkinson's disease (PDMCI)

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SP - 9

EP - 20

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

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