Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

Claudio Babiloni; Claudio Del Percio; Roberta Lizio; Giuseppe Noce; Susanna Lopez; Andrea Soricelli; Raffaele Ferri; Maria Teresa Pascarelli; Valentina Catania; Flavio Nobili; Dario Arnaldi; Francesco Famà; Francesco Orzi; Carla Buttinelli; Franco Giubilei; Laura Bonanni; Raffaella Franciotti; Marco Onofrj; Paola Stirpe; Peter Fuhr; Ute Gschwandtner; Gerhard Ransmayr; Lucia Fraioli; Lucilla Parnetti; Lucia Farotti; Michela Pievani; Fabrizia D'Antonio; Carlo De Lena; Bahar Güntekin; Lutfu Hanoğlu; Görsev Yener; Derya Durusu Emek-Savaş; Antonio Ivano Triggiani; John Paul Taylor; Ian McKeith; Fabrizio Stocchi; Laura Vacca; Giovanni B Frisoni; Maria Francesca De Pandis

doi:10.1016/j.neurobiolaging.2018.08.010

Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter FuhrUte Gschwandtner, Gerhard Ransmayr, Lucia Fraioli, Lucilla Parnetti, Lucia Farotti, Michela Pievani, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, John Paul Taylor, Ian McKeith, Fabrizio Stocchi, Laura Vacca, Giovanni B Frisoni, Maria Francesca De Pandis

Research output: Contribution to journal › Article › peer-review

Abstract

We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (

Original language	English
Pages (from-to)	9-20
Number of pages	12
Journal	Neurobiol. Aging
Volume	73
DOIs	https://doi.org/10.1016/j.neurobiolaging.2018.08.010
Publication status	Published - Aug 30 2018

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10.1016/j.neurobiolaging.2018.08.010

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Babiloni, C., Del Percio, C., Lizio, R., Noce, G., Lopez, S., Soricelli, A., Ferri, R., Pascarelli, M. T., Catania, V., Nobili, F., Arnaldi, D., Famà, F., Orzi, F., Buttinelli, C., Giubilei, F., Bonanni, L., Franciotti, R., Onofrj, M., Stirpe, P., ... De Pandis, M. F. (2018). Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms. Neurobiol. Aging, 73, 9-20. https://doi.org/10.1016/j.neurobiolaging.2018.08.010

Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms. / Babiloni, Claudio; Del Percio, Claudio; Lizio, Roberta ; Noce, Giuseppe; Lopez, Susanna; Soricelli, Andrea; Ferri, Raffaele ; Pascarelli, Maria Teresa ; Catania, Valentina ; Nobili, Flavio ; Arnaldi, Dario ; Famà, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Bonanni, Laura; Franciotti, Raffaella; Onofrj, Marco; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Fraioli, Lucia; Parnetti, Lucilla; Farotti, Lucia; Pievani, Michela; D'Antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Hanoğlu, Lutfu; Yener, Görsev; Emek-Savaş, Derya Durusu; Triggiani, Antonio Ivano; Taylor, John Paul; McKeith, Ian; Stocchi, Fabrizio ; Vacca, Laura; Frisoni, Giovanni B; De Pandis, Maria Francesca.

In: Neurobiol. Aging, Vol. 73, 30.08.2018, p. 9-20.

Research output: Contribution to journal › Article › peer-review

Babiloni, C, Del Percio, C, Lizio, R , Noce, G, Lopez, S, Soricelli, A, Ferri, R , Pascarelli, MT , Catania, V , Nobili, F , Arnaldi, D , Famà, F, Orzi, F, Buttinelli, C, Giubilei, F, Bonanni, L, Franciotti, R, Onofrj, M, Stirpe, P, Fuhr, P, Gschwandtner, U, Ransmayr, G, Fraioli, L, Parnetti, L, Farotti, L, Pievani, M, D'Antonio, F, De Lena, C, Güntekin, B, Hanoğlu, L, Yener, G, Emek-Savaş, DD, Triggiani, AI, Taylor, JP, McKeith, I, Stocchi, F , Vacca, L, Frisoni, GB & De Pandis, MF 2018, 'Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms', Neurobiol. Aging, vol. 73, pp. 9-20. https://doi.org/10.1016/j.neurobiolaging.2018.08.010

Babiloni, Claudio ; Del Percio, Claudio ; Lizio, Roberta ; Noce, Giuseppe ; Lopez, Susanna ; Soricelli, Andrea ; Ferri, Raffaele ; Pascarelli, Maria Teresa ; Catania, Valentina ; Nobili, Flavio ; Arnaldi, Dario ; Famà, Francesco ; Orzi, Francesco ; Buttinelli, Carla ; Giubilei, Franco ; Bonanni, Laura ; Franciotti, Raffaella ; Onofrj, Marco ; Stirpe, Paola ; Fuhr, Peter ; Gschwandtner, Ute ; Ransmayr, Gerhard ; Fraioli, Lucia ; Parnetti, Lucilla ; Farotti, Lucia ; Pievani, Michela ; D'Antonio, Fabrizia ; De Lena, Carlo ; Güntekin, Bahar ; Hanoğlu, Lutfu ; Yener, Görsev ; Emek-Savaş, Derya Durusu ; Triggiani, Antonio Ivano ; Taylor, John Paul ; McKeith, Ian ; Stocchi, Fabrizio ; Vacca, Laura ; Frisoni, Giovanni B ; De Pandis, Maria Francesca. / Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms. In: Neurobiol. Aging. 2018 ; Vol. 73. pp. 9-20.

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title = "Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms",

abstract = "We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (",

author = "Claudio Babiloni and {Del Percio}, Claudio and Roberta Lizio and Giuseppe Noce and Susanna Lopez and Andrea Soricelli and Raffaele Ferri and Pascarelli, {Maria Teresa} and Valentina Catania and Flavio Nobili and Dario Arnaldi and Francesco Fam{\`a} and Francesco Orzi and Carla Buttinelli and Franco Giubilei and Laura Bonanni and Raffaella Franciotti and Marco Onofrj and Paola Stirpe and Peter Fuhr and Ute Gschwandtner and Gerhard Ransmayr and Lucia Fraioli and Lucilla Parnetti and Lucia Farotti and Michela Pievani and Fabrizia D'Antonio and {De Lena}, Carlo and Bahar G{\"u}ntekin and Lutfu Hanoğlu and G{\"o}rsev Yener and Emek-Sava{\c s}, {Derya Durusu} and Triggiani, {Antonio Ivano} and Taylor, {John Paul} and Ian McKeith and Fabrizio Stocchi and Laura Vacca and Frisoni, {Giovanni B} and {De Pandis}, {Maria Francesca}",

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AU - Babiloni, Claudio

AU - Del Percio, Claudio

AU - Lizio, Roberta

AU - Noce, Giuseppe

AU - Lopez, Susanna

AU - Soricelli, Andrea

AU - Ferri, Raffaele

AU - Pascarelli, Maria Teresa

AU - Catania, Valentina

AU - Nobili, Flavio

AU - Arnaldi, Dario

AU - Famà, Francesco

AU - Orzi, Francesco

AU - Buttinelli, Carla

AU - Giubilei, Franco

AU - Bonanni, Laura

AU - Franciotti, Raffaella

AU - Onofrj, Marco

AU - Stirpe, Paola

AU - Fuhr, Peter

AU - Gschwandtner, Ute

AU - Ransmayr, Gerhard

AU - Fraioli, Lucia

AU - Parnetti, Lucilla

AU - Farotti, Lucia

AU - Pievani, Michela

AU - D'Antonio, Fabrizia

AU - De Lena, Carlo

AU - Güntekin, Bahar

AU - Hanoğlu, Lutfu

AU - Yener, Görsev

AU - Emek-Savaş, Derya Durusu

AU - Triggiani, Antonio Ivano

AU - Taylor, John Paul

AU - McKeith, Ian

AU - Stocchi, Fabrizio

AU - Vacca, Laura

AU - Frisoni, Giovanni B

AU - De Pandis, Maria Francesca

PY - 2018/8/30

Y1 - 2018/8/30

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AB - We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (

U2 - 10.1016/j.neurobiolaging.2018.08.010

DO - 10.1016/j.neurobiolaging.2018.08.010

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JF - Neurobiol. Aging

SN - 0197-4580

ER -

Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

Abstract

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