Levofloxacin disposition over time in aqueous humor of patients undergoing cataract surgery

Federico Pea, Ettore Ferrari, Federica Pavan, Derri Roman-Pognuz, Francesco Bandello, Mario Furlanut

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The ocular disposition of levofloxacin in patients receiving two 500-mg oral doses 10 h apart before cataract surgery was assessed with the intent of defining drug ocular exposure over time. The mean aqueous humor concentrations persisted above 1.5 mg/liter between 1.5 and 6.0 h after the second dose, with average aqueous-to-plasma ratios ranging between 0.33 and 0.57. This favorable ocular disposition provides support for trials of systemic levofloxacin for prophylaxis of postoperative endophthalmitis in selected patients or as adjunctive therapy for the treatment of this potentially devastating infective complication.

Original languageEnglish
Pages (from-to)2554-2557
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number6
DOIs
Publication statusPublished - Jun 2005

Fingerprint

Levofloxacin
Aqueous Humor
Cataract
Endophthalmitis
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Levofloxacin disposition over time in aqueous humor of patients undergoing cataract surgery. / Pea, Federico; Ferrari, Ettore; Pavan, Federica; Roman-Pognuz, Derri; Bandello, Francesco; Furlanut, Mario.

In: Antimicrobial Agents and Chemotherapy, Vol. 49, No. 6, 06.2005, p. 2554-2557.

Research output: Contribution to journalArticle

Pea, Federico ; Ferrari, Ettore ; Pavan, Federica ; Roman-Pognuz, Derri ; Bandello, Francesco ; Furlanut, Mario. / Levofloxacin disposition over time in aqueous humor of patients undergoing cataract surgery. In: Antimicrobial Agents and Chemotherapy. 2005 ; Vol. 49, No. 6. pp. 2554-2557.
@article{f5458729686f472f9a50b62d05b8ac4e,
title = "Levofloxacin disposition over time in aqueous humor of patients undergoing cataract surgery",
abstract = "The ocular disposition of levofloxacin in patients receiving two 500-mg oral doses 10 h apart before cataract surgery was assessed with the intent of defining drug ocular exposure over time. The mean aqueous humor concentrations persisted above 1.5 mg/liter between 1.5 and 6.0 h after the second dose, with average aqueous-to-plasma ratios ranging between 0.33 and 0.57. This favorable ocular disposition provides support for trials of systemic levofloxacin for prophylaxis of postoperative endophthalmitis in selected patients or as adjunctive therapy for the treatment of this potentially devastating infective complication.",
author = "Federico Pea and Ettore Ferrari and Federica Pavan and Derri Roman-Pognuz and Francesco Bandello and Mario Furlanut",
year = "2005",
month = "6",
doi = "10.1128/AAC.49.6.2554-2557.2005",
language = "English",
volume = "49",
pages = "2554--2557",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "6",

}

TY - JOUR

T1 - Levofloxacin disposition over time in aqueous humor of patients undergoing cataract surgery

AU - Pea, Federico

AU - Ferrari, Ettore

AU - Pavan, Federica

AU - Roman-Pognuz, Derri

AU - Bandello, Francesco

AU - Furlanut, Mario

PY - 2005/6

Y1 - 2005/6

N2 - The ocular disposition of levofloxacin in patients receiving two 500-mg oral doses 10 h apart before cataract surgery was assessed with the intent of defining drug ocular exposure over time. The mean aqueous humor concentrations persisted above 1.5 mg/liter between 1.5 and 6.0 h after the second dose, with average aqueous-to-plasma ratios ranging between 0.33 and 0.57. This favorable ocular disposition provides support for trials of systemic levofloxacin for prophylaxis of postoperative endophthalmitis in selected patients or as adjunctive therapy for the treatment of this potentially devastating infective complication.

AB - The ocular disposition of levofloxacin in patients receiving two 500-mg oral doses 10 h apart before cataract surgery was assessed with the intent of defining drug ocular exposure over time. The mean aqueous humor concentrations persisted above 1.5 mg/liter between 1.5 and 6.0 h after the second dose, with average aqueous-to-plasma ratios ranging between 0.33 and 0.57. This favorable ocular disposition provides support for trials of systemic levofloxacin for prophylaxis of postoperative endophthalmitis in selected patients or as adjunctive therapy for the treatment of this potentially devastating infective complication.

UR - http://www.scopus.com/inward/record.url?scp=19544372449&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19544372449&partnerID=8YFLogxK

U2 - 10.1128/AAC.49.6.2554-2557.2005

DO - 10.1128/AAC.49.6.2554-2557.2005

M3 - Article

C2 - 15917572

AN - SCOPUS:19544372449

VL - 49

SP - 2554

EP - 2557

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 6

ER -