Levofloxacin disposition over time in aqueous humor of patients undergoing cataract surgery

Federico Pea, Ettore Ferrari, Federica Pavan, Derri Roman-Pognuz, Francesco Bandello, Mario Furlanut

Research output: Contribution to journalArticle

Abstract

The ocular disposition of levofloxacin in patients receiving two 500-mg oral doses 10 h apart before cataract surgery was assessed with the intent of defining drug ocular exposure over time. The mean aqueous humor concentrations persisted above 1.5 mg/liter between 1.5 and 6.0 h after the second dose, with average aqueous-to-plasma ratios ranging between 0.33 and 0.57. This favorable ocular disposition provides support for trials of systemic levofloxacin for prophylaxis of postoperative endophthalmitis in selected patients or as adjunctive therapy for the treatment of this potentially devastating infective complication.

Original languageEnglish
Pages (from-to)2554-2557
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number6
DOIs
Publication statusPublished - Jun 2005

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ASJC Scopus subject areas

  • Pharmacology (medical)

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