Levofloxacin/amoxicillin-based schemes vs quadruple therapy for helicobacter pylori eradication in second-line

Simona Di Caro, Lucia Fini, Yayha Daoud, Fabio Grizzi, Antonio Gasbarrini, Antonino De Lorenzo, Laura Di Renzo, Sara McCartney, Stuart Bloom

Research output: Contribution to journalArticlepeer-review


Worldwide prevalence of Helicobacter pylori (H. pylori) infection is approximately 50%, with the highest being in developing countries. We compared cure rates and tolerability (SE) of second-line anti-H. pylori levofloxacin/ amoxicillin (LA)-based triple regimens vs standard quadruple therapy (QT). An English language literature search was performed up to October 2010. A meta-analysis was performed including randomized clinical trials comparing 7- or 10-d LA with 7-d QT. In total, 10 articles and four abstracts were identified. Overall eradication rate in LA was 76.5% (95% CI: 64.4%-97.6%). When only 7-d regimens were included, cure rate was 70.6% (95% CI: 40.2%-99.1%), whereas for 10-d combinations, cure rate was significantly higher (88.7%; 95% CI: 56.1%-109.9%; P <0.05). Main eradication rate for QT was 67.4% (95% CI: 49.7%-67.9%). The 7-d LA and QT showed comparable efficacy [odds ratio (OR): 1.09; 95% CI: 0.63-1.87], whereas the 10-d LA regimen was significantly more effective than QT (OR: 5.05; 95% CI: 2.74-9.31; P <0.001; I2 = 75%). No differences were reported in QT eradication rates among Asian and European studies, whereas LA regimens were more effective in European populations (78.3% vs 67.7%; P = 0.05). Incidence of SE was lower in LA therapy than QT (OR: 0.39; 95% CI: 0.18-0.85; P = 0.02). A higher rate of side effects was reported in Asian patients who received QT. Our findings support the use of 10-d LA as a simple second-line treatment for H. pylori eradication with an excellent eradication rate and tolerability. The optimal second-line alternative scheme might differ among countries depending on quinolone resistance.

Original languageEnglish
Pages (from-to)5669-5678
Number of pages10
JournalWorld Journal of Gastroenterology
Issue number40
Publication statusPublished - 2012


  • Helicobacter pylori
  • Levofloxacin
  • Quadruple regimen
  • Second-line treatment

ASJC Scopus subject areas

  • Gastroenterology


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