Levonantradol, a new antiemetic with a high rate of side-effects for the prevention of nausea and vomiting in patients receiving cancer chemotherapy

Rudolf A. Joss, Renato L. Galeazzi, Annakatharina Bischoff, Do D. Do, Aron Goldhirsch, Kurt W. Brunner

Research output: Contribution to journalArticle

Abstract

Levonantradol, a new antiemetic compound pharmacologically related to the cannabinoids, was given to 17 patients who had experienced severe and protracted nausea and vomiting during previous courses of cancer chemotherapy, and to six patients receiving a first course of strongly emetic cytostatic treatment. Eight patients were partially protected from acute gastrointestinal disturbances. Of the 23 patients, 21 exhibited some toxicity, with six patients exhibiting major affective side-effects and 13 patients complaining of pain at the injection site. Levonantradol is an active antiemetic compound. Due to the rate of side-effects observed in our study however, we would not recommend use of this agent as an antiemetic drug.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalCancer Chemotherapy and Pharmacology
Volume9
Issue number1
DOIs
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pharmacology

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