Levosimendan in two neonates with ischemic heart failure and pulmonary hypertension

Maria Pia De Carolis, Marco Piastra, Iliana Bersani, Manuela Pardeo, Eleonora Stival, Alessia Tempera, Costantino Romagnoli, Giorgio Conti, Gabriella De Rosa

Research output: Contribution to journalArticlepeer-review


We report the successful and safe use of levosimendan, a new calcium-sensitizing agent with positive inotropic and vasodilatory action, in 2 critically ill term newborns with acute heart failure and pulmonary hypertension in the absence of any underlying heart malformation and/or previous cardiosurgical procedures. During the neonatal period, levosimendan may represent an ideal drug for immature myocardium characterized by a higher calcium-dependent contractility than in adults.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
Issue number3
Publication statusPublished - Mar 2012


  • Heart failure
  • Heart ischemia
  • Levosimendan
  • Low cardiac output syndrome
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health


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