LFA-1 expression by blood eosinophils is increased in atopic asthmatic children and is involved in eosinophil locomotion

S. Lantero, G. Alessandri, D. Spallarossa, L. Scarso, G. A. Rossi

Research output: Contribution to journalArticlepeer-review

Abstract

Allergic asthma is characterized by eosinophil migration in the airways, which is strictly dependent on the expression of adhesion molecules. This study investigated whether the expression of adhesion molecules on eosinophils is increased and associated with disease activity in allergic asthma. Twenty atopic asthmatic (AA) subjects and nine controls were studied and the expression of lymphocyte function-associated antigen-1 (LFA-1; CD11a/CD18), Mac-1 (CD11b/CD18) and very late antigen-4 (VLA-4; CD49d/CD29) on blood eosinophils was evaluated by specific monoclonal antibody (Mab) staining and flow-cytometric analysis. Compared with controls, eosinophils from AA showed increased expression of LFA-1 (p0.1). In addition, LFA-1 expression correlated positively with blood eosinophil number (r=0.792, p0.1). Thus, the expression of lymphocyte function-associated antigen-1 by blood eosinophils is increased in atopic asthmatics and seems to modulate the enhanced eosinophil migration observed in allergic asthma.

Original languageEnglish
Pages (from-to)1094-1098
Number of pages5
JournalEuropean Respiratory Journal
Volume12
Issue number5
Publication statusPublished - Nov 1998

Keywords

  • Adhesion molecules
  • Allergic asthma
  • Cell migration
  • Eosinophils

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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