We characterized the LGI1/Epitempin protein product and determined its distribution in the human brain by Western blot. Two brain-specific proteins of about 60 and 65 kDa were detected by a polyclonal antibody, lmmunoblot analysis of tissue samples from various human brain regions revealed differential expression of both proteins. Notably, the two proteins were found to be more abundant in the lateral temporal cortex than in the hippocampus, suggesting a possible molecular mechanism leading to lateral temporal epilepsy.
|Translated title of the contribution||LGI1/Epitempin: Differential protein expression in brain regions|
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 2005|
ASJC Scopus subject areas
- Clinical Neurology