Lgr5 expression, cancer stem cells and pancreatic cancer: Results from biological and computational analyses

Kalliopi Andrikou, Matteo Santoni, Francesco Piva, Alessandro Bittoni, Andrea Lanese, Chiara Pellei, Alessandro Conti, Cristian Loretelli, Alessandra Mandolesi, Matteo Giulietti, Marina Scarpelli, Giovanni Principato, Massimo Falconi, Stefano Cascinu

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To determine the relationship between Lgr5 and other stemness markers and pathologic features in pancreatic ductal adenocarcinoma (PDAC) samples. Materials & methods: In 69 samples, Lgr5 was analyzed by qRT-PCR together with a panel of 29 genes. Bioinformatic analysis was carried out to identify a possible pathway regulating Lgr5 expression in PDAC. Results: Lgr5 expression was not associated with the expression of tested cancer stem cell markers. Moreover, it was not an independent predictor of survival neither at univariate analysis (p = 0.21) nor at multivariate analysis (p = 0.225). Conclusion: Based on the lack of correlation between Lgr5 and tested cancer stem cell markers, Lgr5 does not seem to be a potential stemness marker or prognostic factor in PDAC.

Original languageEnglish
Pages (from-to)1037-1045
Number of pages9
JournalFuture Oncology
Volume11
Issue number7
DOIs
Publication statusPublished - Apr 1 2015

Keywords

  • cancer stem cell
  • embryonic signaling pathways
  • Lgr5
  • overall survival
  • pancreatic ductal adenocarcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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