TY - JOUR
T1 - Lichen planopilaris after imiquimod 5% cream for multiple BCC in basal cell naevus syndrome
AU - Drummond, Alessandra
AU - Pichler, Janine
AU - Argenziano, Giuseppe
AU - Zalaudek, Iris
AU - Longo, Caterina
AU - Lallas, Aimilios
AU - Piana, Simonetta
AU - Moscarella, Elvira
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Basal cell naevus syndrome is an inherited autosomal dominant genetic disorder characterised by multiple basal cell carcinomas (BCC), skeletal, neurological and opthalmological abnormalities. The treatment of choice of the often multiple and large BCC consists of a combined approach including surgery, liquid nitrogen and other topical treatment modalities. Imiquimod 5% cream is an immune-response-modifying drug with antiviral and anti-tumour activity. Recent reports have associated the immune-stimulant properties of imiquimod with the exacerbation of several autoimmune skin diseases, such as eczema, psoriasis, vitiligo and lichenoid dermatitis. Here we report a patient with basal cell naevus syndrome who developed a lichen planopilaris on the same site of the scalp, which had been previously treated with two cycles of imiquimod for multiple BCC.
AB - Basal cell naevus syndrome is an inherited autosomal dominant genetic disorder characterised by multiple basal cell carcinomas (BCC), skeletal, neurological and opthalmological abnormalities. The treatment of choice of the often multiple and large BCC consists of a combined approach including surgery, liquid nitrogen and other topical treatment modalities. Imiquimod 5% cream is an immune-response-modifying drug with antiviral and anti-tumour activity. Recent reports have associated the immune-stimulant properties of imiquimod with the exacerbation of several autoimmune skin diseases, such as eczema, psoriasis, vitiligo and lichenoid dermatitis. Here we report a patient with basal cell naevus syndrome who developed a lichen planopilaris on the same site of the scalp, which had been previously treated with two cycles of imiquimod for multiple BCC.
KW - Gorlin-Goltz
KW - imiquimod 5%
KW - lichen planopilaris
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U2 - 10.1111/ajd.12151
DO - 10.1111/ajd.12151
M3 - Article
AN - SCOPUS:84956698656
VL - 56
SP - e105-e107
JO - Australasian Journal of Dermatology
JF - Australasian Journal of Dermatology
SN - 0004-8380
IS - 4
ER -