Lichen sclerosus and the risk of malignant progression: A case series of 159 patients

G. Paolino, C. Panetta, C. Cota, L. Muscardin, P. Donati, A. Di Carlo

Research output: Contribution to journalArticlepeer-review


Aim and methods. We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous- hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females. In the cases of SCC, immunohistochemical analyses was performed. Results and conclusion. The results showed very low positivity to p16INK4A and Ki-67; biomolecular PCR was positive in only two cases, and in both cases the non-oncogenic genotype HPV 100 was detected. No important additional risk factors for malignancies were found (e.g., hormones, infections, other autoimmune diseases).

Original languageEnglish
Pages (from-to)673-678
Number of pages6
JournalGiornale Italiano di Dermatologia e Venereologia
Issue number6
Publication statusPublished - 2013


  • Hyperplasia
  • Lichen sclerosus et atrophicus
  • Penile neoplasms

ASJC Scopus subject areas

  • Dermatology


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