Lichen sclerosus and the risk of malignant progression

A case series of 159 patients

G. Paolino, C. Panetta, C. Cota, L. Muscardin, P. Donati, A. Di Carlo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim and methods. We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous- hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females. In the cases of SCC, immunohistochemical analyses was performed. Results and conclusion. The results showed very low positivity to p16INK4A and Ki-67; biomolecular PCR was positive in only two cases, and in both cases the non-oncogenic genotype HPV 100 was detected. No important additional risk factors for malignancies were found (e.g., hormones, infections, other autoimmune diseases).

Original languageEnglish
Pages (from-to)673-678
Number of pages6
JournalGiornale Italiano di Dermatologia e Venereologia
Volume148
Issue number6
Publication statusPublished - 2013

Fingerprint

Lichen Sclerosus et Atrophicus
Carcinoma
Autoimmune Diseases
Hyperplasia
Neoplasms
Genotype
Hormones
Polymerase Chain Reaction
Infection

Keywords

  • Hyperplasia
  • Lichen sclerosus et atrophicus
  • Penile neoplasms

ASJC Scopus subject areas

  • Dermatology

Cite this

Lichen sclerosus and the risk of malignant progression : A case series of 159 patients. / Paolino, G.; Panetta, C.; Cota, C.; Muscardin, L.; Donati, P.; Di Carlo, A.

In: Giornale Italiano di Dermatologia e Venereologia, Vol. 148, No. 6, 2013, p. 673-678.

Research output: Contribution to journalArticle

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AU - Panetta, C.

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AU - Muscardin, L.

AU - Donati, P.

AU - Di Carlo, A.

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N2 - Aim and methods. We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous- hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females. In the cases of SCC, immunohistochemical analyses was performed. Results and conclusion. The results showed very low positivity to p16INK4A and Ki-67; biomolecular PCR was positive in only two cases, and in both cases the non-oncogenic genotype HPV 100 was detected. No important additional risk factors for malignancies were found (e.g., hormones, infections, other autoimmune diseases).

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