Lichen sclerosus and the risk of malignant progression: A case series of 159 patients

G. Paolino; C. Panetta; C. Cota; L. Muscardin; P. Donati; A. Di Carlo

Lichen sclerosus and the risk of malignant progression: A case series of 159 patients

G. Paolino, C. Panetta, C. Cota, L. Muscardin, P. Donati, A. Di Carlo

Istituto S. Maria e S. Gallicano

Research output: Contribution to journal › Article › peer-review

Abstract

Aim and methods. We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous- hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females. In the cases of SCC, immunohistochemical analyses was performed. Results and conclusion. The results showed very low positivity to p16^INK4A and Ki-67; biomolecular PCR was positive in only two cases, and in both cases the non-oncogenic genotype HPV 100 was detected. No important additional risk factors for malignancies were found (e.g., hormones, infections, other autoimmune diseases).

Original language	English
Pages (from-to)	673-678
Number of pages	6
Journal	Giornale Italiano di Dermatologia e Venereologia
Volume	148
Issue number	6
Publication status	Published - 2013

Keywords

Hyperplasia
Lichen sclerosus et atrophicus
Penile neoplasms

ASJC Scopus subject areas

Dermatology

Cite this

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title = "Lichen sclerosus and the risk of malignant progression: A case series of 159 patients",

abstract = "Aim and methods. We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous- hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females. In the cases of SCC, immunohistochemical analyses was performed. Results and conclusion. The results showed very low positivity to p16INK4A and Ki-67; biomolecular PCR was positive in only two cases, and in both cases the non-oncogenic genotype HPV 100 was detected. No important additional risk factors for malignancies were found (e.g., hormones, infections, other autoimmune diseases).",

keywords = "Hyperplasia, Lichen sclerosus et atrophicus, Penile neoplasms",

author = "G. Paolino and C. Panetta and C. Cota and L. Muscardin and P. Donati and {Di Carlo}, A.",

year = "2013",

language = "English",

volume = "148",

pages = "673--678",

journal = "Minerva dermatologica",

issn = "0392-0488",

publisher = "Edizioni Minerva Medica S.p.A.",

number = "6",

}

TY - JOUR

T1 - Lichen sclerosus and the risk of malignant progression

T2 - A case series of 159 patients

AU - Paolino, G.

AU - Panetta, C.

AU - Cota, C.

AU - Muscardin, L.

AU - Donati, P.

AU - Di Carlo, A.

PY - 2013

Y1 - 2013

N2 - Aim and methods. We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous- hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females. In the cases of SCC, immunohistochemical analyses was performed. Results and conclusion. The results showed very low positivity to p16INK4A and Ki-67; biomolecular PCR was positive in only two cases, and in both cases the non-oncogenic genotype HPV 100 was detected. No important additional risk factors for malignancies were found (e.g., hormones, infections, other autoimmune diseases).

AB - Aim and methods. We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous- hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females. In the cases of SCC, immunohistochemical analyses was performed. Results and conclusion. The results showed very low positivity to p16INK4A and Ki-67; biomolecular PCR was positive in only two cases, and in both cases the non-oncogenic genotype HPV 100 was detected. No important additional risk factors for malignancies were found (e.g., hormones, infections, other autoimmune diseases).

KW - Hyperplasia

KW - Lichen sclerosus et atrophicus

KW - Penile neoplasms

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M3 - Article

C2 - 24442050

AN - SCOPUS:84895824032

VL - 148

SP - 673

EP - 678

JO - Minerva dermatologica

JF - Minerva dermatologica

SN - 0392-0488

IS - 6

ER -

Lichen sclerosus and the risk of malignant progression: A case series of 159 patients

Abstract

Keywords

ASJC Scopus subject areas

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