Abstract
Aim and methods. We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous- hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females. In the cases of SCC, immunohistochemical analyses was performed. Results and conclusion. The results showed very low positivity to p16INK4A and Ki-67; biomolecular PCR was positive in only two cases, and in both cases the non-oncogenic genotype HPV 100 was detected. No important additional risk factors for malignancies were found (e.g., hormones, infections, other autoimmune diseases).
| Original language | English |
|---|---|
| Pages (from-to) | 673-678 |
| Number of pages | 6 |
| Journal | Giornale Italiano di Dermatologia e Venereologia |
| Volume | 148 |
| Issue number | 6 |
| Publication status | Published - 2013 |
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Keywords
- Hyperplasia
- Lichen sclerosus et atrophicus
- Penile neoplasms
ASJC Scopus subject areas
- Dermatology
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Lichen sclerosus and the risk of malignant progression : A case series of 159 patients. / Paolino, G.; Panetta, C.; Cota, C.; Muscardin, L.; Donati, P.; Di Carlo, A.
In: Giornale Italiano di Dermatologia e Venereologia, Vol. 148, No. 6, 2013, p. 673-678.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lichen sclerosus and the risk of malignant progression
T2 - A case series of 159 patients
AU - Paolino, G.
AU - Panetta, C.
AU - Cota, C.
AU - Muscardin, L.
AU - Donati, P.
AU - Di Carlo, A.
PY - 2013
Y1 - 2013
N2 - Aim and methods. We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous- hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females. In the cases of SCC, immunohistochemical analyses was performed. Results and conclusion. The results showed very low positivity to p16INK4A and Ki-67; biomolecular PCR was positive in only two cases, and in both cases the non-oncogenic genotype HPV 100 was detected. No important additional risk factors for malignancies were found (e.g., hormones, infections, other autoimmune diseases).
AB - Aim and methods. We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous- hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females. In the cases of SCC, immunohistochemical analyses was performed. Results and conclusion. The results showed very low positivity to p16INK4A and Ki-67; biomolecular PCR was positive in only two cases, and in both cases the non-oncogenic genotype HPV 100 was detected. No important additional risk factors for malignancies were found (e.g., hormones, infections, other autoimmune diseases).
KW - Hyperplasia
KW - Lichen sclerosus et atrophicus
KW - Penile neoplasms
UR - http://www.scopus.com/inward/record.url?scp=84895824032&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84895824032&partnerID=8YFLogxK
M3 - Article
C2 - 24442050
AN - SCOPUS:84895824032
VL - 148
SP - 673
EP - 678
JO - Minerva dermatologica
JF - Minerva dermatologica
SN - 0392-0488
IS - 6
ER -