Lichen sclerosus of the vulva

Massimo Origoni, Chiara Gelardi, Stefano Salvatore, Massimo Candiani

Research output: Contribution to journalArticle

Abstract

Lichen sclerosus is a non-neoplastic chronic inflammatory dermatosis that can affect any cutaneous body surface, showing particular predilection for the anogenital area in females. It is clinically characterized by progressive and worsening degeneration of the dermal/epidermal layers, which determines hyperkeratinization, and a thick scar-like appearance of the external genitalia. Very often, atrophic changes of the genital structures - labia majora and minora, clitoris and vulvar vestibule - are evident with architectural alterations of the genitalia that cause significant sexual discomfort. Chronic and severe vulvar itching, especially at night, is the predominant symptom reported by almost all patients. Diagnosis is often delayed by long-term self-administered topical preparations, or by the clinician's unawareness of the disease. Indeed, the condition is often misdiagnosed as an aspecific vulvitis. Postmenopausal women are more frequently affected, but young girls and even children may also suffer from vulvar lichen sclerosus. It is now generally accepted as an autoimmune disorder, although its exact pathogenesis remains unclear and controversial, as does its potential role in the onset of vulvar cancer.

Original languageEnglish
Pages (from-to)57-65
Number of pages9
JournalExpert Review of Obstetrics and Gynecology
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Vulvar Lichen Sclerosus
Genitalia
Vulvitis
Clitoris
Lichen Sclerosus et Atrophicus
Vulvar Neoplasms
Skin
Pruritus
Diagnostic Errors
Skin Diseases
Cicatrix

Keywords

  • lichen sclerosus
  • vulva
  • vulvar lichen sclerosus

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Maternity and Midwifery
  • Pediatrics, Perinatology, and Child Health

Cite this

Lichen sclerosus of the vulva. / Origoni, Massimo; Gelardi, Chiara; Salvatore, Stefano; Candiani, Massimo.

In: Expert Review of Obstetrics and Gynecology, Vol. 8, No. 1, 01.2013, p. 57-65.

Research output: Contribution to journalArticle

Origoni, Massimo ; Gelardi, Chiara ; Salvatore, Stefano ; Candiani, Massimo. / Lichen sclerosus of the vulva. In: Expert Review of Obstetrics and Gynecology. 2013 ; Vol. 8, No. 1. pp. 57-65.
@article{f4a7bb88c1fd414e839baf6a488f283e,
title = "Lichen sclerosus of the vulva",
abstract = "Lichen sclerosus is a non-neoplastic chronic inflammatory dermatosis that can affect any cutaneous body surface, showing particular predilection for the anogenital area in females. It is clinically characterized by progressive and worsening degeneration of the dermal/epidermal layers, which determines hyperkeratinization, and a thick scar-like appearance of the external genitalia. Very often, atrophic changes of the genital structures - labia majora and minora, clitoris and vulvar vestibule - are evident with architectural alterations of the genitalia that cause significant sexual discomfort. Chronic and severe vulvar itching, especially at night, is the predominant symptom reported by almost all patients. Diagnosis is often delayed by long-term self-administered topical preparations, or by the clinician's unawareness of the disease. Indeed, the condition is often misdiagnosed as an aspecific vulvitis. Postmenopausal women are more frequently affected, but young girls and even children may also suffer from vulvar lichen sclerosus. It is now generally accepted as an autoimmune disorder, although its exact pathogenesis remains unclear and controversial, as does its potential role in the onset of vulvar cancer.",
keywords = "lichen sclerosus, vulva, vulvar lichen sclerosus",
author = "Massimo Origoni and Chiara Gelardi and Stefano Salvatore and Massimo Candiani",
year = "2013",
month = "1",
doi = "10.1586/eog.12.71",
language = "English",
volume = "8",
pages = "57--65",
journal = "Expert Review of Obstetrics and Gynecology",
issn = "1747-4108",
publisher = "Expert Reviews Ltd.",
number = "1",

}

TY - JOUR

T1 - Lichen sclerosus of the vulva

AU - Origoni, Massimo

AU - Gelardi, Chiara

AU - Salvatore, Stefano

AU - Candiani, Massimo

PY - 2013/1

Y1 - 2013/1

N2 - Lichen sclerosus is a non-neoplastic chronic inflammatory dermatosis that can affect any cutaneous body surface, showing particular predilection for the anogenital area in females. It is clinically characterized by progressive and worsening degeneration of the dermal/epidermal layers, which determines hyperkeratinization, and a thick scar-like appearance of the external genitalia. Very often, atrophic changes of the genital structures - labia majora and minora, clitoris and vulvar vestibule - are evident with architectural alterations of the genitalia that cause significant sexual discomfort. Chronic and severe vulvar itching, especially at night, is the predominant symptom reported by almost all patients. Diagnosis is often delayed by long-term self-administered topical preparations, or by the clinician's unawareness of the disease. Indeed, the condition is often misdiagnosed as an aspecific vulvitis. Postmenopausal women are more frequently affected, but young girls and even children may also suffer from vulvar lichen sclerosus. It is now generally accepted as an autoimmune disorder, although its exact pathogenesis remains unclear and controversial, as does its potential role in the onset of vulvar cancer.

AB - Lichen sclerosus is a non-neoplastic chronic inflammatory dermatosis that can affect any cutaneous body surface, showing particular predilection for the anogenital area in females. It is clinically characterized by progressive and worsening degeneration of the dermal/epidermal layers, which determines hyperkeratinization, and a thick scar-like appearance of the external genitalia. Very often, atrophic changes of the genital structures - labia majora and minora, clitoris and vulvar vestibule - are evident with architectural alterations of the genitalia that cause significant sexual discomfort. Chronic and severe vulvar itching, especially at night, is the predominant symptom reported by almost all patients. Diagnosis is often delayed by long-term self-administered topical preparations, or by the clinician's unawareness of the disease. Indeed, the condition is often misdiagnosed as an aspecific vulvitis. Postmenopausal women are more frequently affected, but young girls and even children may also suffer from vulvar lichen sclerosus. It is now generally accepted as an autoimmune disorder, although its exact pathogenesis remains unclear and controversial, as does its potential role in the onset of vulvar cancer.

KW - lichen sclerosus

KW - vulva

KW - vulvar lichen sclerosus

UR - http://www.scopus.com/inward/record.url?scp=84871992235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871992235&partnerID=8YFLogxK

U2 - 10.1586/eog.12.71

DO - 10.1586/eog.12.71

M3 - Article

AN - SCOPUS:84871992235

VL - 8

SP - 57

EP - 65

JO - Expert Review of Obstetrics and Gynecology

JF - Expert Review of Obstetrics and Gynecology

SN - 1747-4108

IS - 1

ER -