Lichen striatus - A chameleon: An histopathological and immunohistological study of forty-one cases

R. Gianotti, L. Restano, R. Grimalt, E. Berti, E. Alessi, R. Caputo

Research output: Contribution to journalArticle

Abstract

Lichen striatus (LS) is an uncommon dermatosis that generally affects children. The histopathology of LS often shows a polymorphic epidermal reaction process of variable lichenoid and spongiotic changes having no specific histopathological criteria or simulating- other diseases. In the present study, we have evaluated the histopathological features of 41 biopsy specimens and the immunohistochemical aspects of 10 cases of LS. In 50% of the cases, we found histopathological and immunopathological features constantly present and allowing a correct diagnosis. In 9 cases, the histopathology was not specific, and in 10 cases, a clear differentiation from other diseases was not possible. Immunohistochemical study demonstrated a CD3+ T-lymphocytic infiltration in which CD8+ cells surrounded necrotic keratinocytes and intraepidermal vesicles filled with Langerhans cells. These findings seem to corroborate the hypothesis that a somatic mutation of a keratinocytic clone could induce an autoimmune response of the host.

Original languageEnglish
Pages (from-to)18-22
Number of pages5
JournalJournal of Cutaneous Pathology
Volume22
Issue number1
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

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