Life expectancy and prognostic factors for survival in patients with polycythemia vera and essential thrombocythemia

Francesco Passamonti, Elisa Rumi, Ester Pungolino, Lucia Malabarba, Paola Bertazzoni, Marina Valentini, Ester Orlandi, Luca Arcaini, Ercole Brusamolino, Cristiana Pascutto, Mario Cazzola, Enrica Morra, Mario Lazzarino

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Abstract

To assess life expectancy and prognostic factors for survival in patients with polycythemia vera and essential thrombocythemia. The study sample consisted of 831 consecutive patients with polycythemia vera (n = 396; 4184 person-years of follow-up) or essential thrombocythemia (n = 435; 4304 person-years of follow-up). Mortality in each group was compared with the Italian population using the standardized mortality ratio (SMR) based on life expectancy data obtained from the Italian Institute of Statistics. The 15-year survival was 65% in patients with polycythemia and 73% in those with thrombocythemia. By Cox regression analysis, the independent predictors of death were a history of thrombosis for polycythemia (hazard ratio [HR] = 2.2; P = 0.0002) and thrombocythemia (HR = 2; P = 0.01), and male sex (HR = 1.8; P = 0.03) for thrombocythemia. Mortality compared with the general population was 1.6-fold higher (P

Original languageEnglish
Pages (from-to)755-761
Number of pages7
JournalAmerican Journal of Medicine
Volume117
Issue number10
DOIs
Publication statusPublished - Nov 15 2004

ASJC Scopus subject areas

  • Nursing(all)

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    Passamonti, F., Rumi, E., Pungolino, E., Malabarba, L., Bertazzoni, P., Valentini, M., Orlandi, E., Arcaini, L., Brusamolino, E., Pascutto, C., Cazzola, M., Morra, E., & Lazzarino, M. (2004). Life expectancy and prognostic factors for survival in patients with polycythemia vera and essential thrombocythemia. American Journal of Medicine, 117(10), 755-761. https://doi.org/10.1016/j.amjmed.2004.06.032