Life expectancy of young adults with follicular lymphoma

A. Conconi, C. Lobetti-Bodoni, S. Montoto, A. Lopez-Guillermo, R. Coutinho, J. Matthews, S. Franceschetti, F. Bertoni, A. Moccia, P. M V Rancoita, J. Gribben, F. Cavalli, G. Gaidano, T. A. Lister, E. Montserrat, M. Ghielmini, Emanuele Zucca

Research output: Contribution to journalArticle

Abstract

Background: This study was aimed at investigating the clinical features and outcomes of follicular lymphoma (FL) patients younger than 40 years, which have not been extensively investigated yet. Patients and methods: One hundred and fifty-five patients younger than 40 years were retrospectively studied from a series of 1002 FL patients diagnosed in four different European Oncology Centres (Barcelona, Spain; Bellinzona, Switzerland; London, UK; Novara, Italy) from 1985 to 2010. Results: Patients younger than 40 had a lower incidence of elevated LDH, high beta2-microglobulin, and a high-risk Follicular Lymphoma International Prognostic Index (FLIPI) score, whereas bone marrow involvement and bulky and disseminated lymphadenopathy were more frequent. At a median follow-up of 10 years, younger patients, in comparison with those older than 40, had significantly better overall (OS), cause-specific survival (CSS), and progression-free survival (PFS), with 10-year OS rate of 81% versus 51% (P <0.0001), 10-year CSS rate of 82% versus 60% (P <0.0001), and 10-year PFS of 39% versus 24% (P = 0.0098). However, there were no significant CSS and PFS differences in comparison with the patients aged 40-60. In multivariate analysis, having the lymphoma diagnosed in the last two decades and a favourable FLIPI score were associated with a significantly longer PFS and CSS in younger patients, whereas only FLIPI retained statistical significance for OS. Conclusions: In our series, FL patients younger than 40 have a median OS of 24 years and their outcome seems to be improving over time. However, they still have a significantly shorter life expectancy than that of an age-matched general healthy population.

Original languageEnglish
Article numbermdv376
Pages (from-to)2317-2322
Number of pages6
JournalAnnals of Oncology
Volume26
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • age
  • Follicular lymphoma
  • life expectancy
  • prognosis
  • survival
  • young adults

ASJC Scopus subject areas

  • Oncology
  • Hematology

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    Conconi, A., Lobetti-Bodoni, C., Montoto, S., Lopez-Guillermo, A., Coutinho, R., Matthews, J., Franceschetti, S., Bertoni, F., Moccia, A., Rancoita, P. M. V., Gribben, J., Cavalli, F., Gaidano, G., Lister, T. A., Montserrat, E., Ghielmini, M., & Zucca, E. (2015). Life expectancy of young adults with follicular lymphoma. Annals of Oncology, 26(11), 2317-2322. [mdv376]. https://doi.org/10.1093/annonc/mdv376