Life-style and metformin for the prevention of endometrial pathology in postmenopausal women

Carlo Campagnoli, Chiara Abbà, Simona Ambroggio, Tiziana Brucato, Patrizia Pasanisi

Research output: Contribution to journalArticlepeer-review

Abstract

In western women, the endometrium is frequently exposed, even after menopause, to the endogenous hormonal stimulation. Such a stimulation increases the risk of pathologic conditions such as endometrial hyperplasia and type I (endometrioid) endometrial adenocarcinoma. Metabolic syndrome, obesity, insulin resistance and type II diabetes promote the endometrial stimulation, and are recognized risk factors for endometrial cancer. Furthermore, chronic hyperinsulinemia linked both to obesity and metabolic syndrome influences endometrial proliferation through direct and indirect actions. Intentional weight loss, calorie restriction and physical activity are associated with a reduced risk of the endometrial pathology. Biological mechanisms include reduction in insulin and sex steroid hormone levels. In addition to life-style modifications, the antidiabetic metformin may be proposed as preventive agent. Metformin reduces the metabolic syndrome, lowers insulin and testosterone levels in postmenopausal women, and it is a potent inhibitor of endometrial cancer cell proliferation.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalGynecological Endocrinology
Volume29
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Endometrial cancer
  • Endometrial hyperplasia
  • Insulin
  • Metformin
  • Sex hormones

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Obstetrics and Gynaecology

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