Abstract
BACKGROUND: The effect of modifying lifestyle at middle age on mortality has been sparsely examined.
METHODS: Men and women aged 50-54 years randomised to the control group (no intervention) in the population-based Norwegian Colorectal Cancer Prevention trial were asked to fill in lifestyle questionnaires in 2001 and 2004. Lifestyle scores were estimated ranging from 0 (poorest) to 4 (best) based on health recommendations (non-smoking, daily physical activity, body mass index <25.0 kg/m2and healthy diet). Outcomes were all-cause, cancer and cardiovascular mortality before 31 December 2013.
RESULTS: Of the 6886 attainable individuals included in the study, 4211 (61%) responded to the baseline questionnaire in 2001. After a median follow-up of 12.3 years, 226 (5.4%) of the baseline questionnaire responders died; 110 (49%) from cancer and 32 (14%) from cardiovascular disease. For each increment in lifestyle score in 2001, a 21% lower all-cause mortality was observed (HR 0.79, 95% CI 0.67 to 0.94, adjusted for age, sex, occupational working hours and chronic disease or pain during 3 years before enrolment). A one-point increase in lifestyle score from 2001 to 2004 was associated with a 38% reduction in all-cause mortality (adjusted HR 0.62, CI 0.45 to 0.84). The group reporting lifestyle change from score 0-1 (unfavourable) in 2001 to score 2-4 (favourable) in 2004 had 4.8 fewer deaths per 1000 person years, compared with the group maintaining an 'unfavourable' lifestyle (adjusted HR 0.31, CI 0.13 to 0.70 for all-cause mortality).
CONCLUSIONS: Favourable lifestyle changes at age 50-60 years may prevent early death.
TRIAL REGISTRATION: NCT00119912; pre-results.
| Original language | English |
|---|---|
| Pages (from-to) | 59-66 |
| Number of pages | 8 |
| Journal | Journal of Epidemiology and Community Health |
| Volume | 71 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2017 |
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Keywords
- Cardiovascular Diseases/mortality
- Cause of Death
- Colonoscopy
- Colorectal Neoplasms/diagnosis
- Female
- Follow-Up Studies
- Healthy Lifestyle
- Humans
- Male
- Middle Aged
- Neoplasms/mortality
- Norway
- Prospective Studies
- Risk Factors
- Surveys and Questionnaires
- Survival Analysis
Cite this
Lifestyle changes at middle age and mortality : a population-based prospective cohort study. / Berstad, Paula; Botteri, Edoardo; Larsen, Inger Kristin; Løberg, Magnus; Kalager, Mette; Holme, Øyvind; Bretthauer, Michael; Hoff, Geir.
In: Journal of Epidemiology and Community Health, Vol. 71, No. 1, 01.2017, p. 59-66.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lifestyle changes at middle age and mortality
T2 - a population-based prospective cohort study
AU - Berstad, Paula
AU - Botteri, Edoardo
AU - Larsen, Inger Kristin
AU - Løberg, Magnus
AU - Kalager, Mette
AU - Holme, Øyvind
AU - Bretthauer, Michael
AU - Hoff, Geir
N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
PY - 2017/1
Y1 - 2017/1
N2 - BACKGROUND: The effect of modifying lifestyle at middle age on mortality has been sparsely examined.METHODS: Men and women aged 50-54 years randomised to the control group (no intervention) in the population-based Norwegian Colorectal Cancer Prevention trial were asked to fill in lifestyle questionnaires in 2001 and 2004. Lifestyle scores were estimated ranging from 0 (poorest) to 4 (best) based on health recommendations (non-smoking, daily physical activity, body mass index <25.0 kg/m2and healthy diet). Outcomes were all-cause, cancer and cardiovascular mortality before 31 December 2013.RESULTS: Of the 6886 attainable individuals included in the study, 4211 (61%) responded to the baseline questionnaire in 2001. After a median follow-up of 12.3 years, 226 (5.4%) of the baseline questionnaire responders died; 110 (49%) from cancer and 32 (14%) from cardiovascular disease. For each increment in lifestyle score in 2001, a 21% lower all-cause mortality was observed (HR 0.79, 95% CI 0.67 to 0.94, adjusted for age, sex, occupational working hours and chronic disease or pain during 3 years before enrolment). A one-point increase in lifestyle score from 2001 to 2004 was associated with a 38% reduction in all-cause mortality (adjusted HR 0.62, CI 0.45 to 0.84). The group reporting lifestyle change from score 0-1 (unfavourable) in 2001 to score 2-4 (favourable) in 2004 had 4.8 fewer deaths per 1000 person years, compared with the group maintaining an 'unfavourable' lifestyle (adjusted HR 0.31, CI 0.13 to 0.70 for all-cause mortality).CONCLUSIONS: Favourable lifestyle changes at age 50-60 years may prevent early death.TRIAL REGISTRATION: NCT00119912; pre-results.
AB - BACKGROUND: The effect of modifying lifestyle at middle age on mortality has been sparsely examined.METHODS: Men and women aged 50-54 years randomised to the control group (no intervention) in the population-based Norwegian Colorectal Cancer Prevention trial were asked to fill in lifestyle questionnaires in 2001 and 2004. Lifestyle scores were estimated ranging from 0 (poorest) to 4 (best) based on health recommendations (non-smoking, daily physical activity, body mass index <25.0 kg/m2and healthy diet). Outcomes were all-cause, cancer and cardiovascular mortality before 31 December 2013.RESULTS: Of the 6886 attainable individuals included in the study, 4211 (61%) responded to the baseline questionnaire in 2001. After a median follow-up of 12.3 years, 226 (5.4%) of the baseline questionnaire responders died; 110 (49%) from cancer and 32 (14%) from cardiovascular disease. For each increment in lifestyle score in 2001, a 21% lower all-cause mortality was observed (HR 0.79, 95% CI 0.67 to 0.94, adjusted for age, sex, occupational working hours and chronic disease or pain during 3 years before enrolment). A one-point increase in lifestyle score from 2001 to 2004 was associated with a 38% reduction in all-cause mortality (adjusted HR 0.62, CI 0.45 to 0.84). The group reporting lifestyle change from score 0-1 (unfavourable) in 2001 to score 2-4 (favourable) in 2004 had 4.8 fewer deaths per 1000 person years, compared with the group maintaining an 'unfavourable' lifestyle (adjusted HR 0.31, CI 0.13 to 0.70 for all-cause mortality).CONCLUSIONS: Favourable lifestyle changes at age 50-60 years may prevent early death.TRIAL REGISTRATION: NCT00119912; pre-results.
KW - Cardiovascular Diseases/mortality
KW - Cause of Death
KW - Colonoscopy
KW - Colorectal Neoplasms/diagnosis
KW - Female
KW - Follow-Up Studies
KW - Healthy Lifestyle
KW - Humans
KW - Male
KW - Middle Aged
KW - Neoplasms/mortality
KW - Norway
KW - Prospective Studies
KW - Risk Factors
KW - Surveys and Questionnaires
KW - Survival Analysis
U2 - 10.1136/jech-2015-206760
DO - 10.1136/jech-2015-206760
M3 - Article
C2 - 27312250
VL - 71
SP - 59
EP - 66
JO - Journal of Epidemiology and Community Health
JF - Journal of Epidemiology and Community Health
SN - 0143-005X
IS - 1
ER -