TY - JOUR
T1 - Lifestyle factors and risk of leukemia and non-Hodgkin’s lymphoma
T2 - a case–control study
AU - Parodi, Stefano
AU - Santi, Irene
AU - Marani, Enza
AU - Casella, Claudia
AU - Puppo, Antonella
AU - Garrone, Elsa
AU - Fontana, Vincenzo
AU - Stagnaro, Emanuele
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Purpose: Risk factors for leukemia and lymphomas in adults are largely unknown. This study was aimed at evaluating the association between lifestyle factors and the risk of hematological malignancies in an adult population. Methods: Data were drawn from a population-based case–control study carried out in Italy and included 294 cases (199 lymphoid and 95 myeloid) and 279 controls. Analyses were performed using standard multivariable logistic regression. Results: Hair dye use for at least 15 years was associated with a higher risk of lymphoid malignancies among females (OR 2.3, 95 % CI 1.0–4.9, p = 0.036, test for trend). Furthermore, a protective effect of a moderate to heavy tea consumption on the risk of myeloid malignancies was observed (OR 0.4, 95 % CI 0.2–0.9, p = 0.017). No association was found for the use of alcoholic beverages and tobacco smoking. Conclusions: Our results confirm the potential carcinogenic effect of prolonged hair dye use observed in previous investigations. The excess risk could be explained by exposure to a higher concentration of toxic compounds in hair products used in the past. The protective effect of regular tea consumption observed in an area with a very high prevalence of black tea consumers deserves further investigation.
AB - Purpose: Risk factors for leukemia and lymphomas in adults are largely unknown. This study was aimed at evaluating the association between lifestyle factors and the risk of hematological malignancies in an adult population. Methods: Data were drawn from a population-based case–control study carried out in Italy and included 294 cases (199 lymphoid and 95 myeloid) and 279 controls. Analyses were performed using standard multivariable logistic regression. Results: Hair dye use for at least 15 years was associated with a higher risk of lymphoid malignancies among females (OR 2.3, 95 % CI 1.0–4.9, p = 0.036, test for trend). Furthermore, a protective effect of a moderate to heavy tea consumption on the risk of myeloid malignancies was observed (OR 0.4, 95 % CI 0.2–0.9, p = 0.017). No association was found for the use of alcoholic beverages and tobacco smoking. Conclusions: Our results confirm the potential carcinogenic effect of prolonged hair dye use observed in previous investigations. The excess risk could be explained by exposure to a higher concentration of toxic compounds in hair products used in the past. The protective effect of regular tea consumption observed in an area with a very high prevalence of black tea consumers deserves further investigation.
KW - Alcohol
KW - Case–control study
KW - Coffee
KW - Hair dyes
KW - Hemolymphopoietic malignancies
KW - Tea
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UR - http://www.scopus.com/inward/citedby.url?scp=84958759146&partnerID=8YFLogxK
U2 - 10.1007/s10552-016-0713-x
DO - 10.1007/s10552-016-0713-x
M3 - Article
C2 - 26759332
AN - SCOPUS:84958759146
VL - 27
SP - 367
EP - 375
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 3
ER -