Lifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study

Sabine Naudin, Kuanrong Li, Tristan Jaouen, Nada Assi, Cecilie Kyrø, Anne Tjønneland, Kim Overvad, Marie-Christine Boutron-Ruault, Vinciane Rebours, Anne-Laure Védié, Heiner Boeing, Rudolf Kaaks, Verena Katzke, Christina Bamia, Androniki Naska, Antonia Trichopoulou, Franco Berrino, Giovanna Tagliabue, Domenico Palli, Salvatore PanicoRosario Tumino, Carlotta Sacerdote, Petra H Peeters, H B As Bueno-de-Mesquita, Elisabete Weiderpass, Inger Torhild Gram, Guri Skeie, Maria-Dolores Chirlaque, Miguel Rodríguez-Barranco, Aurelio Barricarte, Jose Ramón Quirós, Miren Dorronsoro, Ingegerd Johansson, Malin Sund, Hanna Sternby, Kathryn E Bradbury, Nick Wareham, Elio Riboli, Marc Gunter, Paul Brennan, Eric J Duell, Pietro Ferrari

Research output: Contribution to journalArticle

Abstract

Recent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In our study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer-free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and their 95% confidence interval (CI). Alcohol intake was positively associated with PC risk in men. Associations were mainly driven by extreme alcohol levels, with HRs comparing heavy drinkers (>60 g/day) to the reference category (0.1-4.9 g/day) equal to 1.77 (95% CI: 1.06, 2.95) and 1.63 (95% CI: 1.16, 2.29) for lifetime and baseline alcohol, respectively. Baseline alcohol intakes from beer (>40 g/day) and spirits/liquors (>10 g/day) showed HRs equal to 1.58 (95% CI: 1.07, 2.34) and 1.41 (95% CI: 1.03, 1.94), respectively, compared to the reference category (0.1-2.9 g/day). In women, HR estimates did not reach statistically significance. The alcohol and PC risk association was not modified by smoking status. Findings from a large prospective study suggest that baseline and lifetime alcohol intakes were positively associated with PC risk, with more apparent risk estimates for beer and spirits/liquors than wine intake.

Original languageEnglish
Pages (from-to)801-812
Number of pages12
JournalInternational Journal of Cancer
Volume143
Issue number4
DOIs
Publication statusPublished - Aug 15 2018

Keywords

  • Adult
  • Alcohol Drinking/adverse effects
  • Alcoholic Beverages
  • Alcoholism/complications
  • Confounding Factors (Epidemiology)
  • Diet
  • Dose-Response Relationship, Drug
  • Europe/epidemiology
  • Female
  • Humans
  • Life Style
  • Male
  • Middle Aged
  • Pancreatic Neoplasms/epidemiology
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Smoking/adverse effects
  • Surveys and Questionnaires

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  • Cite this

    Naudin, S., Li, K., Jaouen, T., Assi, N., Kyrø, C., Tjønneland, A., Overvad, K., Boutron-Ruault, M-C., Rebours, V., Védié, A-L., Boeing, H., Kaaks, R., Katzke, V., Bamia, C., Naska, A., Trichopoulou, A., Berrino, F., Tagliabue, G., Palli, D., ... Ferrari, P. (2018). Lifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study. International Journal of Cancer, 143(4), 801-812. https://doi.org/10.1002/ijc.31367