Abstract
Background: There is convincing evidence that alcohol consumption increases the risk of cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx. Most of the data derive from studies that focused on the effect of moderate/high alcohol intakes, while little is known about light alcohol drinking (up to 1 drink/day). Patients and methods: We evaluated the association between light drinking and cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx, through a meta-analytic approach. We searched epidemiological studies using PubMed, ISI Web of Science and EMBASE, published before December 2010. Results: We included 222 articles comprising ~92 000 light drinkers and 60 000 non-drinkers with cancer. Light drinking was associated with the risk of oropharyngeal cancer [relative risk, RR = 1.17; 95% confidence interval (CI) 1.06-1.29], esophageal squamous cell carcinoma (SCC) (RR = 1.30; 95% CI 1.09-1.56) and female breast cancer (RR = 1.05; 95% CI 1.02-1.08). We estimated that ~5000 deaths from oropharyngeal cancer, 24 000 from esophageal SCC and 5000 from breast cancer were attributable to light drinking in 2004 worldwide. No association was found for colorectum, liver and larynx tumors. Conclusions: Light drinking increases the risk of cancer of oral cavity and pharynx, esophagus and female breast.
| Original language | English |
|---|---|
| Article number | mds337 |
| Pages (from-to) | 301-308 |
| Number of pages | 8 |
| Journal | Annals of Oncology |
| Volume | 24 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2013 |
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Keywords
- Alcohol
- Cancer
- Lifestyle
- Meta-analysis
- Public health
- Risk factor
ASJC Scopus subject areas
- Oncology
- Hematology
Cite this
Light alcohol drinking and cancer : A meta-analysis. / Bagnardi, V.; Rota, M.; Botteri, E.; Tramacere, I.; Islami, F.; Fedirko, V.; Scotti, L.; Jenab, M.; Turati, F.; Pasquali, E.; Pelucchi, C.; Bellocco, R.; Negri, E.; Corrao, G.; Rehm, J.; Boffetta, P.; La Vecchia, C.
In: Annals of Oncology, Vol. 24, No. 2, mds337, 02.2013, p. 301-308.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Light alcohol drinking and cancer
T2 - A meta-analysis
AU - Bagnardi, V.
AU - Rota, M.
AU - Botteri, E.
AU - Tramacere, I.
AU - Islami, F.
AU - Fedirko, V.
AU - Scotti, L.
AU - Jenab, M.
AU - Turati, F.
AU - Pasquali, E.
AU - Pelucchi, C.
AU - Bellocco, R.
AU - Negri, E.
AU - Corrao, G.
AU - Rehm, J.
AU - Boffetta, P.
AU - La Vecchia, C.
PY - 2013/2
Y1 - 2013/2
N2 - Background: There is convincing evidence that alcohol consumption increases the risk of cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx. Most of the data derive from studies that focused on the effect of moderate/high alcohol intakes, while little is known about light alcohol drinking (up to 1 drink/day). Patients and methods: We evaluated the association between light drinking and cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx, through a meta-analytic approach. We searched epidemiological studies using PubMed, ISI Web of Science and EMBASE, published before December 2010. Results: We included 222 articles comprising ~92 000 light drinkers and 60 000 non-drinkers with cancer. Light drinking was associated with the risk of oropharyngeal cancer [relative risk, RR = 1.17; 95% confidence interval (CI) 1.06-1.29], esophageal squamous cell carcinoma (SCC) (RR = 1.30; 95% CI 1.09-1.56) and female breast cancer (RR = 1.05; 95% CI 1.02-1.08). We estimated that ~5000 deaths from oropharyngeal cancer, 24 000 from esophageal SCC and 5000 from breast cancer were attributable to light drinking in 2004 worldwide. No association was found for colorectum, liver and larynx tumors. Conclusions: Light drinking increases the risk of cancer of oral cavity and pharynx, esophagus and female breast.
AB - Background: There is convincing evidence that alcohol consumption increases the risk of cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx. Most of the data derive from studies that focused on the effect of moderate/high alcohol intakes, while little is known about light alcohol drinking (up to 1 drink/day). Patients and methods: We evaluated the association between light drinking and cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx, through a meta-analytic approach. We searched epidemiological studies using PubMed, ISI Web of Science and EMBASE, published before December 2010. Results: We included 222 articles comprising ~92 000 light drinkers and 60 000 non-drinkers with cancer. Light drinking was associated with the risk of oropharyngeal cancer [relative risk, RR = 1.17; 95% confidence interval (CI) 1.06-1.29], esophageal squamous cell carcinoma (SCC) (RR = 1.30; 95% CI 1.09-1.56) and female breast cancer (RR = 1.05; 95% CI 1.02-1.08). We estimated that ~5000 deaths from oropharyngeal cancer, 24 000 from esophageal SCC and 5000 from breast cancer were attributable to light drinking in 2004 worldwide. No association was found for colorectum, liver and larynx tumors. Conclusions: Light drinking increases the risk of cancer of oral cavity and pharynx, esophagus and female breast.
KW - Alcohol
KW - Cancer
KW - Lifestyle
KW - Meta-analysis
KW - Public health
KW - Risk factor
UR - http://www.scopus.com/inward/record.url?scp=84873839911&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873839911&partnerID=8YFLogxK
U2 - 10.1093/annonc/mds337
DO - 10.1093/annonc/mds337
M3 - Article
C2 - 22910838
AN - SCOPUS:84873839911
VL - 24
SP - 301
EP - 308
JO - Annals of Oncology
JF - Annals of Oncology
SN - 0923-7534
IS - 2
M1 - mds337
ER -