Light alcohol drinking and cancer: A meta-analysis

V. Bagnardi, M. Rota, E. Botteri, I. Tramacere, F. Islami, V. Fedirko, L. Scotti, M. Jenab, F. Turati, E. Pasquali, C. Pelucchi, R. Bellocco, E. Negri, G. Corrao, J. Rehm, P. Boffetta, C. La Vecchia

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

Background: There is convincing evidence that alcohol consumption increases the risk of cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx. Most of the data derive from studies that focused on the effect of moderate/high alcohol intakes, while little is known about light alcohol drinking (up to 1 drink/day). Patients and methods: We evaluated the association between light drinking and cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx, through a meta-analytic approach. We searched epidemiological studies using PubMed, ISI Web of Science and EMBASE, published before December 2010. Results: We included 222 articles comprising ~92 000 light drinkers and 60 000 non-drinkers with cancer. Light drinking was associated with the risk of oropharyngeal cancer [relative risk, RR = 1.17; 95% confidence interval (CI) 1.06-1.29], esophageal squamous cell carcinoma (SCC) (RR = 1.30; 95% CI 1.09-1.56) and female breast cancer (RR = 1.05; 95% CI 1.02-1.08). We estimated that ~5000 deaths from oropharyngeal cancer, 24 000 from esophageal SCC and 5000 from breast cancer were attributable to light drinking in 2004 worldwide. No association was found for colorectum, liver and larynx tumors. Conclusions: Light drinking increases the risk of cancer of oral cavity and pharynx, esophagus and female breast.

Original languageEnglish
Article numbermds337
Pages (from-to)301-308
Number of pages8
JournalAnnals of Oncology
Volume24
Issue number2
DOIs
Publication statusPublished - Feb 2013

Fingerprint

Alcohol Drinking
Meta-Analysis
Drinking
Light
Larynx
Breast Neoplasms
Esophagus
Oropharyngeal Neoplasms
Mouth
Confidence Intervals
Neoplasms
Pharynx
Liver
Pharyngeal Neoplasms
Mouth Neoplasms
PubMed
Epidemiologic Studies
Breast
Alcohols
Esophageal Squamous Cell Carcinoma

Keywords

  • Alcohol
  • Cancer
  • Lifestyle
  • Meta-analysis
  • Public health
  • Risk factor

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Bagnardi, V., Rota, M., Botteri, E., Tramacere, I., Islami, F., Fedirko, V., ... La Vecchia, C. (2013). Light alcohol drinking and cancer: A meta-analysis. Annals of Oncology, 24(2), 301-308. [mds337]. https://doi.org/10.1093/annonc/mds337

Light alcohol drinking and cancer : A meta-analysis. / Bagnardi, V.; Rota, M.; Botteri, E.; Tramacere, I.; Islami, F.; Fedirko, V.; Scotti, L.; Jenab, M.; Turati, F.; Pasquali, E.; Pelucchi, C.; Bellocco, R.; Negri, E.; Corrao, G.; Rehm, J.; Boffetta, P.; La Vecchia, C.

In: Annals of Oncology, Vol. 24, No. 2, mds337, 02.2013, p. 301-308.

Research output: Contribution to journalArticle

Bagnardi, V, Rota, M, Botteri, E, Tramacere, I, Islami, F, Fedirko, V, Scotti, L, Jenab, M, Turati, F, Pasquali, E, Pelucchi, C, Bellocco, R, Negri, E, Corrao, G, Rehm, J, Boffetta, P & La Vecchia, C 2013, 'Light alcohol drinking and cancer: A meta-analysis', Annals of Oncology, vol. 24, no. 2, mds337, pp. 301-308. https://doi.org/10.1093/annonc/mds337
Bagnardi V, Rota M, Botteri E, Tramacere I, Islami F, Fedirko V et al. Light alcohol drinking and cancer: A meta-analysis. Annals of Oncology. 2013 Feb;24(2):301-308. mds337. https://doi.org/10.1093/annonc/mds337
Bagnardi, V. ; Rota, M. ; Botteri, E. ; Tramacere, I. ; Islami, F. ; Fedirko, V. ; Scotti, L. ; Jenab, M. ; Turati, F. ; Pasquali, E. ; Pelucchi, C. ; Bellocco, R. ; Negri, E. ; Corrao, G. ; Rehm, J. ; Boffetta, P. ; La Vecchia, C. / Light alcohol drinking and cancer : A meta-analysis. In: Annals of Oncology. 2013 ; Vol. 24, No. 2. pp. 301-308.
@article{8e94d8d19fce4b848d78bbf955d73b3b,
title = "Light alcohol drinking and cancer: A meta-analysis",
abstract = "Background: There is convincing evidence that alcohol consumption increases the risk of cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx. Most of the data derive from studies that focused on the effect of moderate/high alcohol intakes, while little is known about light alcohol drinking (up to 1 drink/day). Patients and methods: We evaluated the association between light drinking and cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx, through a meta-analytic approach. We searched epidemiological studies using PubMed, ISI Web of Science and EMBASE, published before December 2010. Results: We included 222 articles comprising ~92 000 light drinkers and 60 000 non-drinkers with cancer. Light drinking was associated with the risk of oropharyngeal cancer [relative risk, RR = 1.17; 95{\%} confidence interval (CI) 1.06-1.29], esophageal squamous cell carcinoma (SCC) (RR = 1.30; 95{\%} CI 1.09-1.56) and female breast cancer (RR = 1.05; 95{\%} CI 1.02-1.08). We estimated that ~5000 deaths from oropharyngeal cancer, 24 000 from esophageal SCC and 5000 from breast cancer were attributable to light drinking in 2004 worldwide. No association was found for colorectum, liver and larynx tumors. Conclusions: Light drinking increases the risk of cancer of oral cavity and pharynx, esophagus and female breast.",
keywords = "Alcohol, Cancer, Lifestyle, Meta-analysis, Public health, Risk factor",
author = "V. Bagnardi and M. Rota and E. Botteri and I. Tramacere and F. Islami and V. Fedirko and L. Scotti and M. Jenab and F. Turati and E. Pasquali and C. Pelucchi and R. Bellocco and E. Negri and G. Corrao and J. Rehm and P. Boffetta and {La Vecchia}, C.",
year = "2013",
month = "2",
doi = "10.1093/annonc/mds337",
language = "English",
volume = "24",
pages = "301--308",
journal = "Annals of Oncology",
issn = "0923-7534",
publisher = "NLM (Medline)",
number = "2",

}

TY - JOUR

T1 - Light alcohol drinking and cancer

T2 - A meta-analysis

AU - Bagnardi, V.

AU - Rota, M.

AU - Botteri, E.

AU - Tramacere, I.

AU - Islami, F.

AU - Fedirko, V.

AU - Scotti, L.

AU - Jenab, M.

AU - Turati, F.

AU - Pasquali, E.

AU - Pelucchi, C.

AU - Bellocco, R.

AU - Negri, E.

AU - Corrao, G.

AU - Rehm, J.

AU - Boffetta, P.

AU - La Vecchia, C.

PY - 2013/2

Y1 - 2013/2

N2 - Background: There is convincing evidence that alcohol consumption increases the risk of cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx. Most of the data derive from studies that focused on the effect of moderate/high alcohol intakes, while little is known about light alcohol drinking (up to 1 drink/day). Patients and methods: We evaluated the association between light drinking and cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx, through a meta-analytic approach. We searched epidemiological studies using PubMed, ISI Web of Science and EMBASE, published before December 2010. Results: We included 222 articles comprising ~92 000 light drinkers and 60 000 non-drinkers with cancer. Light drinking was associated with the risk of oropharyngeal cancer [relative risk, RR = 1.17; 95% confidence interval (CI) 1.06-1.29], esophageal squamous cell carcinoma (SCC) (RR = 1.30; 95% CI 1.09-1.56) and female breast cancer (RR = 1.05; 95% CI 1.02-1.08). We estimated that ~5000 deaths from oropharyngeal cancer, 24 000 from esophageal SCC and 5000 from breast cancer were attributable to light drinking in 2004 worldwide. No association was found for colorectum, liver and larynx tumors. Conclusions: Light drinking increases the risk of cancer of oral cavity and pharynx, esophagus and female breast.

AB - Background: There is convincing evidence that alcohol consumption increases the risk of cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx. Most of the data derive from studies that focused on the effect of moderate/high alcohol intakes, while little is known about light alcohol drinking (up to 1 drink/day). Patients and methods: We evaluated the association between light drinking and cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx, through a meta-analytic approach. We searched epidemiological studies using PubMed, ISI Web of Science and EMBASE, published before December 2010. Results: We included 222 articles comprising ~92 000 light drinkers and 60 000 non-drinkers with cancer. Light drinking was associated with the risk of oropharyngeal cancer [relative risk, RR = 1.17; 95% confidence interval (CI) 1.06-1.29], esophageal squamous cell carcinoma (SCC) (RR = 1.30; 95% CI 1.09-1.56) and female breast cancer (RR = 1.05; 95% CI 1.02-1.08). We estimated that ~5000 deaths from oropharyngeal cancer, 24 000 from esophageal SCC and 5000 from breast cancer were attributable to light drinking in 2004 worldwide. No association was found for colorectum, liver and larynx tumors. Conclusions: Light drinking increases the risk of cancer of oral cavity and pharynx, esophagus and female breast.

KW - Alcohol

KW - Cancer

KW - Lifestyle

KW - Meta-analysis

KW - Public health

KW - Risk factor

UR - http://www.scopus.com/inward/record.url?scp=84873839911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873839911&partnerID=8YFLogxK

U2 - 10.1093/annonc/mds337

DO - 10.1093/annonc/mds337

M3 - Article

C2 - 22910838

AN - SCOPUS:84873839911

VL - 24

SP - 301

EP - 308

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

IS - 2

M1 - mds337

ER -