Ulex europeus 1 lectin (UEA1) has the property to bind fucose, a terminal constituent of many carbohydrate chains that form part of the cell surface glycoproteins. In our study we compared UEA1 binding in psoriatic lesions, in psoriatic uninvolved skin, in normal skin, in sebhorreic keratosis and in viral warts. We used UEA1 biotinylated on frozen sections with fluorescence and peroxidase methods and on fresh tissue with electron-microscopy techniques. UEA1 binding is expressed abnormally on basal and upper-basal layers in psoriatic lesions while in normal skin, uninvolved psoriatic skin and sebhorreic keratosis the UEA1 binding is present only on granulosum and corneum layers. In viral warts UEA1 staining was very similar to psoriatic lesions. Also papillary vessels of psoriatic lesions showed an increase of UEA1 binding. E.M. analysis confirmed the specificity of fucose expression on basal cell keratinocytes in psoriasis.
|Number of pages||4|
|Issue number||SUPPL. 113|
|Publication status||Published - 1984|
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