Light chain crystalline kidney disease: Diagnostic urine microscopy as the "liquid kidney biopsy"

Randy L. Luciano, Ekaterina Castano, Giovanni B. Fogazzi, Mark A. Perazella

Research output: Contribution to journalArticle

Abstract

Multiple myeloma (MM) is a plasma cell disorder, which often causes parenchymal kidney disease. Light chain (LC) cast nephropathy represents the most common renal lesion. In some instances, LC crystals precipitate within renal tubular lumens and deposit within proximal tubular cell cytoplasms. Importantly, urine microscopy in such patients can provide insight into the underlying LC-related lesion. Here we present two patients with MM complicated by acute kidney injury (AKI) where LC crystalline casts were observed on urinary sediment analysis. Kidney biopsy revealed acute tubular injury with LC crystal casts within both tubular lumens and renal tubular epithelial cell cytoplasms. These findings suggest that the urinary sediment may be a non-invasive way to diagnose LC crystalline-induced AKI in patients with MM.

Original languageEnglish
Pages (from-to)387-391
Number of pages5
JournalClinical Nephrology
Volume82
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • Acute kidney injury
  • Crystal casts
  • Light chain cast nephropathy
  • Multiple myeloma

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'Light chain crystalline kidney disease: Diagnostic urine microscopy as the "liquid kidney biopsy"'. Together they form a unique fingerprint.

  • Cite this