Nierenerkrankung mit kristallinen Ablagerungen von Leichtketten

Diagnostische Urinmikroskopie als flüssige Nierenbiopsie

Translated title of the contribution: Light chain crystalline kidney disease: Diagnostic urine microscopy as the liquid kidney biopsy

R. L. Luciano, E. Castano, G. B. Fogazzi, M. A. Perazella

Research output: Contribution to journalArticle

Abstract

Multiple myeloma (MM) is a plasma cell disorder, which often causes parenchymal kidney disease. Light chain (LC) cast nephropathy represents the most common renal lesion. In some instances, LC crystals precipitate within renal tubular lumens and deposit within proximal tubular cell cytoplasms. Importantly, urine microscopy in such patients can provide insight into the underlying LC-related lesion. Here we present two patients with MM complicated by acute kidney injury (AKI) where LC crystalline casts were observed on urinary sediment analysis. Kidney biopsy revealed acute tubular injury with LC crystal casts within both tubular lumens and renal tubular epithelial cell cytoplasms. These findings suggest that the urinary sediment may be a non-invasive way to diagnose LC crystalline-induced AKI in patients with MM.

Original languageGerman
Pages (from-to)166-171
Number of pages6
JournalNieren- und Hochdruckkrankheiten
Volume44
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

Fingerprint

Kidney Diseases
Microscopy
Urine
Kidney
Biopsy
Light
Multiple Myeloma
Acute Kidney Injury
Cytoplasm
Plasma Cells
Epithelial Cells
Wounds and Injuries

Keywords

  • Acute kidney injury
  • Crystal casts
  • Light chain cast nephropathy
  • Multiple myeloma

ASJC Scopus subject areas

  • Nephrology
  • Internal Medicine

Cite this

Nierenerkrankung mit kristallinen Ablagerungen von Leichtketten : Diagnostische Urinmikroskopie als flüssige Nierenbiopsie. / Luciano, R. L.; Castano, E.; Fogazzi, G. B.; Perazella, M. A.

In: Nieren- und Hochdruckkrankheiten, Vol. 44, No. 4, 01.04.2015, p. 166-171.

Research output: Contribution to journalArticle

Luciano, R. L. ; Castano, E. ; Fogazzi, G. B. ; Perazella, M. A. / Nierenerkrankung mit kristallinen Ablagerungen von Leichtketten : Diagnostische Urinmikroskopie als flüssige Nierenbiopsie. In: Nieren- und Hochdruckkrankheiten. 2015 ; Vol. 44, No. 4. pp. 166-171.
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