Light chain deposition disease neuropathy resembling amyloid neuropathy in a multiple myeloma patient

M. P. Grassi; F. Clerici; C. Perin; M. Borella; A. Gendarini; A. Quattrini; R. Nemni; A. Mangoni

Light chain deposition disease neuropathy resembling amyloid neuropathy in a multiple myeloma patient

M. P. Grassi, F. Clerici, C. Perin, M. Borella, A. Gendarini, A. Quattrini, R. Nemni, A. Mangoni

Research output: Contribution to journal › Article › peer-review

Abstract

A 65-year-old man with IgG lambda multiple myeloma developed severe polyneuropathy with prominent thermal-pain sensory impairment and autonomic failure. Although the clinical presentation suggested amyloid neuropathy, nerve biopsy showed the immunohistochemical and ultrastructural features typical of light chain deposition disease (LCDD). A precise morphologic and clinical description of LCDD neuropathy is given for the first time in the present report.

Original language	English
Pages (from-to)	229-233
Number of pages	5
Journal	Italian Journal of Neurological Sciences
Volume	19
Issue number	4
Publication status	Published - 1998

Keywords

Amyloidosis
Light chain deposition disease
Multiple myeloma
Neuropathy

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology
Psychiatry and Mental health
Dermatology

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title = "Light chain deposition disease neuropathy resembling amyloid neuropathy in a multiple myeloma patient",

abstract = "A 65-year-old man with IgG lambda multiple myeloma developed severe polyneuropathy with prominent thermal-pain sensory impairment and autonomic failure. Although the clinical presentation suggested amyloid neuropathy, nerve biopsy showed the immunohistochemical and ultrastructural features typical of light chain deposition disease (LCDD). A precise morphologic and clinical description of LCDD neuropathy is given for the first time in the present report.",

keywords = "Amyloidosis, Light chain deposition disease, Multiple myeloma, Neuropathy",

author = "Grassi, {M. P.} and F. Clerici and C. Perin and M. Borella and A. Gendarini and A. Quattrini and R. Nemni and A. Mangoni",

year = "1998",

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AU - Grassi, M. P.

AU - Clerici, F.

AU - Perin, C.

AU - Borella, M.

AU - Gendarini, A.

AU - Quattrini, A.

AU - Nemni, R.

AU - Mangoni, A.

PY - 1998

Y1 - 1998

N2 - A 65-year-old man with IgG lambda multiple myeloma developed severe polyneuropathy with prominent thermal-pain sensory impairment and autonomic failure. Although the clinical presentation suggested amyloid neuropathy, nerve biopsy showed the immunohistochemical and ultrastructural features typical of light chain deposition disease (LCDD). A precise morphologic and clinical description of LCDD neuropathy is given for the first time in the present report.

AB - A 65-year-old man with IgG lambda multiple myeloma developed severe polyneuropathy with prominent thermal-pain sensory impairment and autonomic failure. Although the clinical presentation suggested amyloid neuropathy, nerve biopsy showed the immunohistochemical and ultrastructural features typical of light chain deposition disease (LCDD). A precise morphologic and clinical description of LCDD neuropathy is given for the first time in the present report.

KW - Amyloidosis

KW - Light chain deposition disease

KW - Multiple myeloma

KW - Neuropathy

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