Abstract
BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by deficits in self-controlling attention, behavior, and emotions. In recent years, noninvasive optical techniques, such as near infrared spectroscopy (NIRS), have been used to measure the neural correlates of pharmacological-therapy outcomes in children and adolescents with ADHD.
METHODS: We reviewed a short series of articles that investigated the results of functional NIRS (fNIRS) on developmental-age ADHD. The review was limited to fNIRS studies that investigated the cortical responses that occurred during neuropsychological tasks in ADHD patients who received methylphenidate or atomoxetine.
RESULTS: The majority of the reviewed studies revealed the presence of increased oxygenated hemoglobin concentrations in the prefrontal cortex following pharmacotherapy in ADHD samples. A higher frequency of right-lateralized results was found.
LIMITATIONS: The considered studies are characterized by substantial methodological heterogeneity in terms of the patients' medication status and washout period, explored cerebral regions, and neuropsychological tasks.
CONCLUSIONS: fNIRS seems to be a promising tool for the detection of pharmacological-treatment biomarkers in samples of children and adolescents with ADHD.
| Original language | English |
|---|---|
| Pages (from-to) | 100-106 |
| Number of pages | 7 |
| Journal | Journal of Affective Disorders |
| Volume | 244 |
| DOIs | |
| Publication status | Published - Feb 1 2019 |
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Light up ADHD : II. Neuropharmacological effects measured by near infrared spectroscopy: is there a biomarker? / Grazioli, Silvia; Mauri, Maddalena; Crippa, Alessandro; Maggioni, Eleonora; Molteni, Massimo; Brambilla, Paolo; Nobile, Maria.
In: Journal of Affective Disorders, Vol. 244, 01.02.2019, p. 100-106.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Light up ADHD
T2 - II. Neuropharmacological effects measured by near infrared spectroscopy: is there a biomarker?
AU - Grazioli, Silvia
AU - Mauri, Maddalena
AU - Crippa, Alessandro
AU - Maggioni, Eleonora
AU - Molteni, Massimo
AU - Brambilla, Paolo
AU - Nobile, Maria
N1 - Copyright © 2018 Elsevier B.V. All rights reserved.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by deficits in self-controlling attention, behavior, and emotions. In recent years, noninvasive optical techniques, such as near infrared spectroscopy (NIRS), have been used to measure the neural correlates of pharmacological-therapy outcomes in children and adolescents with ADHD.METHODS: We reviewed a short series of articles that investigated the results of functional NIRS (fNIRS) on developmental-age ADHD. The review was limited to fNIRS studies that investigated the cortical responses that occurred during neuropsychological tasks in ADHD patients who received methylphenidate or atomoxetine.RESULTS: The majority of the reviewed studies revealed the presence of increased oxygenated hemoglobin concentrations in the prefrontal cortex following pharmacotherapy in ADHD samples. A higher frequency of right-lateralized results was found.LIMITATIONS: The considered studies are characterized by substantial methodological heterogeneity in terms of the patients' medication status and washout period, explored cerebral regions, and neuropsychological tasks.CONCLUSIONS: fNIRS seems to be a promising tool for the detection of pharmacological-treatment biomarkers in samples of children and adolescents with ADHD.
AB - BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by deficits in self-controlling attention, behavior, and emotions. In recent years, noninvasive optical techniques, such as near infrared spectroscopy (NIRS), have been used to measure the neural correlates of pharmacological-therapy outcomes in children and adolescents with ADHD.METHODS: We reviewed a short series of articles that investigated the results of functional NIRS (fNIRS) on developmental-age ADHD. The review was limited to fNIRS studies that investigated the cortical responses that occurred during neuropsychological tasks in ADHD patients who received methylphenidate or atomoxetine.RESULTS: The majority of the reviewed studies revealed the presence of increased oxygenated hemoglobin concentrations in the prefrontal cortex following pharmacotherapy in ADHD samples. A higher frequency of right-lateralized results was found.LIMITATIONS: The considered studies are characterized by substantial methodological heterogeneity in terms of the patients' medication status and washout period, explored cerebral regions, and neuropsychological tasks.CONCLUSIONS: fNIRS seems to be a promising tool for the detection of pharmacological-treatment biomarkers in samples of children and adolescents with ADHD.
U2 - 10.1016/j.jad.2018.10.100
DO - 10.1016/j.jad.2018.10.100
M3 - Review article
C2 - 30332620
VL - 244
SP - 100
EP - 106
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -