Light up ADHD: II. Neuropharmacological effects measured by near infrared spectroscopy: is there a biomarker?

Research output: Contribution to journalReview article

Abstract

BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by deficits in self-controlling attention, behavior, and emotions. In recent years, noninvasive optical techniques, such as near infrared spectroscopy (NIRS), have been used to measure the neural correlates of pharmacological-therapy outcomes in children and adolescents with ADHD.

METHODS: We reviewed a short series of articles that investigated the results of functional NIRS (fNIRS) on developmental-age ADHD. The review was limited to fNIRS studies that investigated the cortical responses that occurred during neuropsychological tasks in ADHD patients who received methylphenidate or atomoxetine.

RESULTS: The majority of the reviewed studies revealed the presence of increased oxygenated hemoglobin concentrations in the prefrontal cortex following pharmacotherapy in ADHD samples. A higher frequency of right-lateralized results was found.

LIMITATIONS: The considered studies are characterized by substantial methodological heterogeneity in terms of the patients' medication status and washout period, explored cerebral regions, and neuropsychological tasks.

CONCLUSIONS: fNIRS seems to be a promising tool for the detection of pharmacological-treatment biomarkers in samples of children and adolescents with ADHD.

Original languageEnglish
Pages (from-to)100-106
Number of pages7
JournalJournal of Affective Disorders
Volume244
DOIs
Publication statusPublished - Feb 1 2019

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Near-Infrared Spectroscopy
Attention Deficit Disorder with Hyperactivity
Biomarkers
Light
Pharmacological Biomarkers
Methylphenidate
Prefrontal Cortex
Emotions
Hemoglobins
Pharmacology
Drug Therapy
Therapeutics

Cite this

@article{eaede4775e7348b5aa1e893491ce2379,
title = "Light up ADHD: II. Neuropharmacological effects measured by near infrared spectroscopy: is there a biomarker?",
abstract = "BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by deficits in self-controlling attention, behavior, and emotions. In recent years, noninvasive optical techniques, such as near infrared spectroscopy (NIRS), have been used to measure the neural correlates of pharmacological-therapy outcomes in children and adolescents with ADHD.METHODS: We reviewed a short series of articles that investigated the results of functional NIRS (fNIRS) on developmental-age ADHD. The review was limited to fNIRS studies that investigated the cortical responses that occurred during neuropsychological tasks in ADHD patients who received methylphenidate or atomoxetine.RESULTS: The majority of the reviewed studies revealed the presence of increased oxygenated hemoglobin concentrations in the prefrontal cortex following pharmacotherapy in ADHD samples. A higher frequency of right-lateralized results was found.LIMITATIONS: The considered studies are characterized by substantial methodological heterogeneity in terms of the patients' medication status and washout period, explored cerebral regions, and neuropsychological tasks.CONCLUSIONS: fNIRS seems to be a promising tool for the detection of pharmacological-treatment biomarkers in samples of children and adolescents with ADHD.",
author = "Silvia Grazioli and Maddalena Mauri and Alessandro Crippa and Eleonora Maggioni and Massimo Molteni and Paolo Brambilla and Maria Nobile",
note = "Copyright {\circledC} 2018 Elsevier B.V. All rights reserved.",
year = "2019",
month = "2",
day = "1",
doi = "10.1016/j.jad.2018.10.100",
language = "English",
volume = "244",
pages = "100--106",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

TY - JOUR

T1 - Light up ADHD

T2 - II. Neuropharmacological effects measured by near infrared spectroscopy: is there a biomarker?

AU - Grazioli, Silvia

AU - Mauri, Maddalena

AU - Crippa, Alessandro

AU - Maggioni, Eleonora

AU - Molteni, Massimo

AU - Brambilla, Paolo

AU - Nobile, Maria

N1 - Copyright © 2018 Elsevier B.V. All rights reserved.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by deficits in self-controlling attention, behavior, and emotions. In recent years, noninvasive optical techniques, such as near infrared spectroscopy (NIRS), have been used to measure the neural correlates of pharmacological-therapy outcomes in children and adolescents with ADHD.METHODS: We reviewed a short series of articles that investigated the results of functional NIRS (fNIRS) on developmental-age ADHD. The review was limited to fNIRS studies that investigated the cortical responses that occurred during neuropsychological tasks in ADHD patients who received methylphenidate or atomoxetine.RESULTS: The majority of the reviewed studies revealed the presence of increased oxygenated hemoglobin concentrations in the prefrontal cortex following pharmacotherapy in ADHD samples. A higher frequency of right-lateralized results was found.LIMITATIONS: The considered studies are characterized by substantial methodological heterogeneity in terms of the patients' medication status and washout period, explored cerebral regions, and neuropsychological tasks.CONCLUSIONS: fNIRS seems to be a promising tool for the detection of pharmacological-treatment biomarkers in samples of children and adolescents with ADHD.

AB - BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by deficits in self-controlling attention, behavior, and emotions. In recent years, noninvasive optical techniques, such as near infrared spectroscopy (NIRS), have been used to measure the neural correlates of pharmacological-therapy outcomes in children and adolescents with ADHD.METHODS: We reviewed a short series of articles that investigated the results of functional NIRS (fNIRS) on developmental-age ADHD. The review was limited to fNIRS studies that investigated the cortical responses that occurred during neuropsychological tasks in ADHD patients who received methylphenidate or atomoxetine.RESULTS: The majority of the reviewed studies revealed the presence of increased oxygenated hemoglobin concentrations in the prefrontal cortex following pharmacotherapy in ADHD samples. A higher frequency of right-lateralized results was found.LIMITATIONS: The considered studies are characterized by substantial methodological heterogeneity in terms of the patients' medication status and washout period, explored cerebral regions, and neuropsychological tasks.CONCLUSIONS: fNIRS seems to be a promising tool for the detection of pharmacological-treatment biomarkers in samples of children and adolescents with ADHD.

U2 - 10.1016/j.jad.2018.10.100

DO - 10.1016/j.jad.2018.10.100

M3 - Review article

C2 - 30332620

VL - 244

SP - 100

EP - 106

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -