TY - JOUR
T1 - Limited importance of pre-embryo pronuclear morphology (zygote score) in assisted reproduction outcome in the absence of embryo cryopreservation
AU - Nicoli, Alessia
AU - Valli, Barbara
AU - Di Girolamo, Roberta
AU - Di Tommaso, Barbara
AU - Gallinelli, Andrea
AU - La Sala, Giovanni B.
PY - 2007/10
Y1 - 2007/10
N2 - Objective: To investigate the hypothesis that Z-score criteria represent a reliable predictor of implantation rate and pregnancy outcome in in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles, excluding the possibility of embryo selection before the embryo transfer. Design: Retrospective clinical study. Setting: Centre of Reproductive Medicine, Department of Obstetrics and Gynecology, Arcispedale S. Maria Nuova (ASMN), Reggio Emilia, Italy. Patient(s): We analyzed 393 pregnancies obtained by IVF or ICSI cycles. Intervention(s): Morphologic evaluations of Z-score in pre-embryos obtained from IVF or ICSI cycles. Main Outcome Measure(s): Evaluations of Z-scores, implantation rate, and clinical pregnancy outcome. Result(s): We did not find any statistically significant correlation between the Z-score of 1032 embryos transferred in 393 embryo transfers and the implantation rate or the pregnancy outcome. In particular, the best Z-score identified (Z1, 7.2%) did not seem to correlate with embryo implantation rate or pregnancy outcomes any better than those with worse scores (Z2, 6.9% and Z3, 85.9%). Conclusion(s): Our results seem to confirm that Z-score alone cannot be considered a better tool than standard morphologic criteria for identifying, controlling, or selecting embryos with a better chance of successful ongoing pregnancy.
AB - Objective: To investigate the hypothesis that Z-score criteria represent a reliable predictor of implantation rate and pregnancy outcome in in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles, excluding the possibility of embryo selection before the embryo transfer. Design: Retrospective clinical study. Setting: Centre of Reproductive Medicine, Department of Obstetrics and Gynecology, Arcispedale S. Maria Nuova (ASMN), Reggio Emilia, Italy. Patient(s): We analyzed 393 pregnancies obtained by IVF or ICSI cycles. Intervention(s): Morphologic evaluations of Z-score in pre-embryos obtained from IVF or ICSI cycles. Main Outcome Measure(s): Evaluations of Z-scores, implantation rate, and clinical pregnancy outcome. Result(s): We did not find any statistically significant correlation between the Z-score of 1032 embryos transferred in 393 embryo transfers and the implantation rate or the pregnancy outcome. In particular, the best Z-score identified (Z1, 7.2%) did not seem to correlate with embryo implantation rate or pregnancy outcomes any better than those with worse scores (Z2, 6.9% and Z3, 85.9%). Conclusion(s): Our results seem to confirm that Z-score alone cannot be considered a better tool than standard morphologic criteria for identifying, controlling, or selecting embryos with a better chance of successful ongoing pregnancy.
KW - ART, IVF
KW - embryo
KW - ICSI
KW - nucleoli
KW - pregnancy
KW - pronuclear morphology
KW - Z-score
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U2 - 10.1016/j.fertnstert.2007.01.066
DO - 10.1016/j.fertnstert.2007.01.066
M3 - Article
C2 - 17467704
AN - SCOPUS:34848839502
VL - 88
SP - 1167
EP - 1173
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 4 SUPPL.
ER -