Limited sampling strategies for the estimation of atazanavir daily exposure in HIV-infected patients

Dario Cattaneo, Diego Ripamonti, Sara Baldelli, Valeria Cozzi, Serena Fucile, Emilio Clementi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Stepwise multiple regression analyses were applied to 44 atazanavir pharmacokinetic profiles from 44 HIV-1 infected patients concomitantly treated with raltegravir with the goal of identifying limited sampling strategies for the prediction of drug AUC0-12. Atazanavir trough-based equations failed to reliably predict daily drug exposure in patients with low drug bioavailability. Conversely, different algorithms based on few samples and associated with good correlation, acceptable bias and imprecision with the measured atazanavir AUC0-12 were identified. These models could be used to predict atazanavir exposure for clinic or research purposes.

Original languageEnglish
Pages (from-to)216-222
Number of pages7
JournalFundamental and Clinical Pharmacology
Volume27
Issue number2
DOIs
Publication statusPublished - Apr 2013

Fingerprint

HIV
Pharmaceutical Preparations
Biological Availability
HIV-1
Pharmacokinetics
Regression Analysis
Atazanavir Sulfate
Research
Raltegravir Potassium

Keywords

  • Atazanavir
  • HIV
  • Limited sampling strategies
  • Pharmacokinetics

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Limited sampling strategies for the estimation of atazanavir daily exposure in HIV-infected patients. / Cattaneo, Dario; Ripamonti, Diego; Baldelli, Sara; Cozzi, Valeria; Fucile, Serena; Clementi, Emilio.

In: Fundamental and Clinical Pharmacology, Vol. 27, No. 2, 04.2013, p. 216-222.

Research output: Contribution to journalArticle

Cattaneo, Dario ; Ripamonti, Diego ; Baldelli, Sara ; Cozzi, Valeria ; Fucile, Serena ; Clementi, Emilio. / Limited sampling strategies for the estimation of atazanavir daily exposure in HIV-infected patients. In: Fundamental and Clinical Pharmacology. 2013 ; Vol. 27, No. 2. pp. 216-222.
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